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Vol. 282, Issue 1, 385-390, 1997
The Angiogenesis Research Center (J.J.L., J.P.C., M.S.),
Cardiovascular Division, Recently, a number of growth factors including basic fibroblast growth
factor (bFGF) have been shown to promote angiogenesis in
vivo. In this study, we evaluated dose-dependent effect of bFGF
administration in the setting of chronic myocardial ischemia. A total
of 18 Yorkshire pigs subjected to ameroid occluder placement on the
left circumflex artery were randomized to treatment with 10 (n = 6) or 100 µg (n = 5) of bFGF
incorporated into heparin-alginate microspheres or inactive control
pellets (n = 7). Eight weeks later, all animals
underwent angiographic evaluation of collateral development as well as
studies of coronary flow and global and regional left ventricular
function. Both bFGF groups had significantly higher angiographic
collateral index, TIMI flow scores and coronary flow in the
ameroid-compromised territory compared with controls. Left ventricular
function studies demonstrated improved global and regional function in
both fibroblast growth factor groups with significantly better
preservation of regional wall motion in high dose (100 µg) bFGF
animals. We conclude that local perivascular delivery of bFGF results
in significant improvement in myocardial function in the setting of
chronic myocardial ischemia.
Copyright © by The American Society for Pharmacology and Experimental Therapeutics
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