![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Vol. 280, Issue 2, 911-918, 1997
Alcohol Research Center and School of Pharmacy, University of
Colorado Health Sciences Center, Denver, Colorado
Genetic correlations were found between high-affinity neurotensin
receptor (NTRH) densities and NT-immunoreactivity (NT-ir) levels in specific brain regions and sensitivity to hypnotic and hypothermic effects of ethanol in LSXSS recombinant inbred strains of
mice. Simple sequence length polymorphisms were used to identify quantitative trait loci (QTL) influencing hypnotic and hypothermic sensitivity to ethanol, NTRH and low-affinity neurotensin
receptor densities and NT-ir levels in LSXSS recombinant inbred
strains. Common QTL for NTRH receptor densities, NT-ir
levels and these ethanol actions were identified. One of the QTL
(chromosome 2, 80 cM) for NTRH density and hypnotic
sensitivity is linked to the NTRH gene, Ntsr.
Also, QTL for NTRH density were found in common with
confirmed QTL for hypnotic sensitivity on chromosomes 1 (43 cM), 11 (57 cM) and 15 (56 cM) and with an unconfirmed QTL on chromosome 3 (19 cM).
Two common QTL for NT-ir levels, but not NTRH or
low-affinity neurotensin receptor receptors, and ethanol-induced hypothermia were observed on chromosomes 4 (43 cM) and 6 (41 cM). Two
common QTL for NT-ir levels and sleep time were identified on
chromosomes 3 (19 cM) and 9 (55 cM). Common QTL indicate that genes
regulating NT receptor and/or NT-ir expression may be the same as those
regulating sensitivity to ethanol.
This article has been cited by other articles:
|
|
 |
|
  V. G. Erwin, R. Radcliffe, and R. A. Deitrich Neurotensin Levels in Specific Brain Regions and Hypnotic Sensitivity to Ethanol and Pentobarbital as a Function of Time after Haloperidol Administration in Selectively Bred Rat Lines J. Pharmacol. Exp. Ther., November 1, 2001; 299(2): 698 - 704. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Demarest, J. McCaughran Jr, E. Mahjubi, L. Cipp, and R. Hitzemann Identification of an Acute Ethanol Response Quantitative Trait Locus on Mouse Chromosome 2 J. Neurosci., January 15, 1999; 19(2): 549 - 561. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. G. Erwin, R. A. Radcliffe, V. M. Gehle, and B. C. Jones Common Quantitative Trait Loci for Alcohol-Related Behaviors and Central Nervous System Neurotensin Measures: Locomotor Activation J. Pharmacol. Exp. Ther., February 1, 1997; 280(2): 919 - 926. [Abstract] [Full Text]
|
|
|
|
 |
|
 L. I. CRAWSHAW, H. L. WALLACE, R. CHRISTENSEN, and J. C. CRABBE Influence of ethanol on thermoregulation: mapping quantitative trait loci Physiol Genomics, December 21, 2001; 7(2): 159 - 169. [Abstract] [Full Text] [PDF]
|
|
 |
 |
 |
|
 |
 |
 |
