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Journal of Pharmacology And Experimental Therapeutics, Vol. 28, Issue 2, 277-285, 1926
Copyright © 1926 by American Society for Pharmacology and Experimental Therapeutics

EFFECTS OF TRIVALENT AND PENTAVALENT ARSENIC ON HEART PULSATIONS OF THE SILKWORM

F. L. CAMPBELL 1

1 From the Entomological laboratory of the Bussey Institution, Harvard University

Three phases of heart activity and of general behavior follow administration to the silkworm of lethal doses of trivalent or of pentavalent arsenic: first, a period of vigorous, regular, and often, accelerated heart pulsations during which the larva is motionless; second, a period of more or less rapid decline in heart rate during which the larva squirms; third, a period of irregular pulsations and diminution in amplitude of beat during which squirming ceases.

Trivalent arsenic seems to differ in its effect from the same dose of pentavalent arsenic only in its greater speed of toxic action.

Submitted on April 15, 1926






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