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Journal of Pharmacology And Experimental Therapeutics, Vol. 28, Issue 2, 241-249, 1926
Copyright © 1926 by American Society for Pharmacology and Experimental Therapeutics

EFFECT OF MORPHINE AND SOME OTHER OPIUM ALKALOIDS ON THE MUSCULAR ACTIVITY OF THE ALIMENTARY CANAL II. INFLUENCE OF CONTINUED ADMINISTRATION OF MORPHINE AND OF WITHDRAWAL ON THE CONTRACTIONSOF SMALL INTESTINES OF DOGS

G. H. MILLER 1 and O. H. PLANT 1

1 From the Laboratory of Pharmacology, State University of Iowa, Iowa City

1. The stimulation of the intestinal muscles by morphine does not disappear when the drug is administered continuously for several weeks. Very small doses continue to produce the reaction after daily administration during six weeks. Small amounts still produce a distinct reaction when ascending doses have been administered for ten weeks.

2. These results indicate that other factors than increased destruction of the drug by the tissues play an important part in the development of morphine tolerance.

Submitted on April 12, 1926




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Copyright © 1926 by the American Society for Pharmacology and Experimental Therapeutics.