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Journal of Pharmacology And Experimental Therapeutics, Vol. 28, Issue 1, 109-119, 1926
Copyright © 1926 by American Society for Pharmacology and Experimental Therapeutics

STUDIES IN THE PHARMACOLOGY OF BISMUTH SALTS III. TOXICITY AND URINARY ELIMINATION OF POTASSIUM BISMUTH TARTRATE

CLIFFORD S. LEONARD 1 and JOHN L. O'BRIEN 1

1 From the Department of Pharmacology and Toxicology, Yale University, New Haven, Connecticut

1. The maximum tolerated intramuscular dose in the rabbit of dipotassium bismuth tartrate is about 150 mgm. per kilo (containing 75 mgm. Bi). One hundred and eighty milligrams per kilo kill in six days, with extensive kidney necrosis.

2. The minimum nephropathic dose of this drug in the rabbit is about 100 mgm. per kilo (in a two-week period).

3. Tables of the daily urinary excretion of bismuth in the rabbit after intramuscular injection of various doses of dipotassium bismuth tartrate are given. The rate of excretion is fairly uniform throughout the survival of the animal after toxic doses, and over a two week period after sub-lethal doses. There is no diminishing rate of excretion such as is shown by the soluble tartrate.

4. There is a lower rate of excretion and lessened total excretion the higher the dose given. This agrees with the extent of the kidney damage.

5. The therapeutic ratio of dipotassium bismuth tartrate is found to be 1/75 (using Hopkins' m.e.d.).

Submitted on March 9, 1926




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Copyright © 1926 by the American Society for Pharmacology and Experimental Therapeutics.