![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
NR Swerdlow, V Bakshi and MA Geyer
Department of Psychiatry and Neurosciences Program, University of California, San Diego, La Jolla 2093-0804, USA.
Phencylidine (PCP) is a psychotomimetic noncompetitive glutamate antagonist that has been used in studies of the neural substrates of psychosis. Both schizophrenic patients and PCP-treated rats exhibit reduced amounts of prepulse inhibition (PPI) of the startle reflex, which is the normal inhibition of startle that occurs when the starting noise is preceded 30 to 500 msec by a weak prepulse. The present study assessed the effects of seroquel (ICI 204,636), a mixed D2/5- hydroxytryptamine2 antagonist with a preclinical profile suggestive of potential antipsychotic efficacy, on the PCP-induced disruption of PPI. Clozapine, risperidone and haloperidol were also studied as comparison compounds. PCP (1.25 mg/kg) significantly reduced PPI, with prepulses that were 1 to 12 dB above background. Seroquel and clozapine significantly restored PPI in PCP-treated rats, whereas haloperidol and risperidone did not. Similar findings were obtained in studies using separate animals, a slightly lower dose of PCP (1.0 mg/kg) and a high dose of each of these antipsychotics. Separate studies verified that risperidone and haloperidol restored PPI in apomorphine-treated rats. In the present studies, seroquel exhibited a profile consistent with those exhibited by other "atypical" antipsychotics.
This article has been cited by other articles:
|
|
 |
|
  J. Cilia, P. Hatcher, C. Reavill, and D. N. C. Jones ({+/-}) Ketamine-induced prepulse inhibition deficits of an acoustic startle response in rats are not reversed by antipsychotics J Psychopharmacol, May 1, 2007; 21(3): 302 - 311. [Abstract] [PDF]
|
|
|
|
|
|
S. J. Graham, J. C. Scaife, A. M. B. Verduzco, R. W. Langley, C. M. Bradshaw, and E. Szabadi Effects of Quetiapine and Haloperidol on Prepulse Inhibition of the Acoustic Startle (Eyeblink) Response and the N1/P2 Auditory Evoked Response in Man J Psychopharmacol, June 1, 2004; 18(2): 173 - 180. [Abstract] [PDF]
|
|
|
|
 |
|
 D. Umbricht, L. Schmid, R. Koller, F. X. Vollenweider, D. Hell, and D. C. Javitt Ketamine-Induced Deficits in Auditory and Visual Context-Dependent Processing in Healthy Volunteers: Implications for Models of Cognitive Deficits in Schizophrenia Arch Gen Psychiatry, December 1, 2000; 57(12): 1139 - 1147. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. R. Swerdlow, Z. A. Martinez, F. M. Hanlon, A. Platten, M. Farid, P. Auerbach, D. L. Braff, and M. A. Geyer Toward Understanding the Biology of a Complex Phenotype: Rat Strain and Substrain Differences in the Sensorimotor Gating-Disruptive Effects of Dopamine Agonists J. Neurosci., June 1, 2000; 20(11): 4325 - 4336. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. E. Duncan, S. Miyamoto, J. N. Leipzig, and J. A. Lieberman Comparison of the Effects of Clozapine, Risperidone, and Olanzapine on Ketamine-Induced Alterations in Regional Brain Metabolism J. Pharmacol. Exp. Ther., April 1, 2000; 293(1): 8 - 14. [Abstract] [Full Text]
|
|
|
|
|
|
S. E. Purdon, B. D. W. Jones, E. Stip, A. Labelle, D. Addington, S. R. David, A. Breier, G. D. Tollefson, and for The Canadian Collaborative Group for Research Neuropsychological Change in Early Phase Schizophrenia During 12 Months of Treatment With Olanzapine, Risperidone, or Haloperidol Arch Gen Psychiatry, March 1, 2000; 57(3): 249 - 258. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Geyer, N. R. Swerdlow, V. Lehmann-Masten, H.-J. Teschendorf, M. Traut, and G. Gross Effects of LU-111995 in Three Models of Disrupted Prepulse Inhibition in Rats J. Pharmacol. Exp. Ther., August 1, 1999; 290(2): 716 - 724. [Abstract] [Full Text]
|
|
|
|
|
|
V. P. Bakshi, M. Tricklebank, H. C. Neijt, V. Lehmann-Masten, and M. A. Geyer Disruption of Prepulse Inhibition and Increases in Locomotor Activity by Competitive N-Methyl-D-aspartate Receptor Antagonists in Rats J. Pharmacol. Exp. Ther., February 1, 1999; 288(2): 643 - 652. [Abstract] [Full Text]
|
|
|
|
|
|
D. Feifel, T. L. Reza, D. J. Wustrow, and M. D. Davis Novel Antipsychotic-Like Effects on Prepulse Inhibition of Startle Produced by a Neurotensin Agonist J. Pharmacol. Exp. Ther., February 1, 1999; 288(2): 710 - 713. [Abstract] [Full Text]
|
|
|
|
|
|
V. P. Bakshi and M. A. Geyer Phencyclidine-Induced Deficits in Prepulse Inhibition of Startle are Blocked by Prazosin, an Alpha-1 Noradrenergic Antagonist J. Pharmacol. Exp. Ther., November 1, 1997; 283(2): 666 - 674. [Abstract] [Full Text]
|
|
 |
 |
 |
|
 |
 |
 |
