JPET Introducing ALZET?ew Model 2006 Pump

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lichtenberger, L. M.
Right arrow Articles by Walters, E. T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lichtenberger, L. M.
Right arrow Articles by Walters, E. T.

Zwitterionic phospholipids enhance aspirin's therapeutic activity, as demonstrated in rodent model systems

LM Lichtenberger, C Ulloa, AL Vanous, JJ Romero, EJ Dial, PA Illich and ET Walters

Department of Integrative Biology, University of Texas-Houston Medical School, USA.

We have recently reported that the Gl toxicity of aspirin is markedly reduced when the drug is preassociated with the zwitterionic phospholipid dipalmitoylphosphatidycholine (DPPC) before intragastric administration. The present study was designed to determine whether the biological availability and therapeutic activity of aspirin were affected by chemically associating the drug with DPPC. To evaluate this, we compared the kinetics of entry of labeled aspirin into the blood, after intragastric administration of the drug in the free and lipid-associated states; we also tested the ability of the above formulations to inhibit fever, inflammation and pain in appropriate rodent model systems. We found that although the Gl absorption of free aspirin and that of the aspirin/DPPC complex were similar, in all three rodent models the complex had significantly greater antipyretic, anti- inflammatory and analgesic efficacy than aspirin alone. Dose-response analyses employing the fever model demonstrated that potency of aspirin to reduce fever was increased 5 to 10-fold when the aspirin was intragastrically administered in the lipid-associated state. We conclude that the therapeutic activity of aspirin to inhibit fever, inflammation and pain is remarkably enhanced when the drug is intragastrically administered in chemical association with the zwitterionic phospholipid DPPC. A number of molecular mechanisms have been proposed to explain the observed phospholipid-dependent increase in aspirin's therapeutic activity.

Volume 277, Issue 3, pp. 1221-1227, 06/01/1996
Copyright © 1996 by American Society for Pharmacology and Experimental Therapeutics




This article has been cited by other articles:


Home page
 Biophys. JHome page
Y. Zhou and R. M. Raphael
Effect of Salicylate on the Elasticity, Bending Stiffness, and Strength of SOPC Membranes
Biophys. J., September 1, 2005; 89(3): 1789 - 1801.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
L. M. Lichtenberger, J. J. Romero, W. M. J. de Ruijter, F. Behbod, R. Darling, A. Q. Ashraf, and S. K. Sanduja
Phosphatidylcholine Association Increases the Anti-Inflammatory and Analgesic Activity of Ibuprofen in Acute and Chronic Rodent Models of Joint Inflammation: Relationship to Alterations in Bioavailability and Cyclooxygenase-Inhibitory Potency
J. Pharmacol. Exp. Ther., July 1, 2001; 298(1): 279 - 287.
[Abstract] [Full Text]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1996 by the American Society for Pharmacology and Experimental Therapeutics.