JPET Assistant Professor of Medicine (Clinician-Educator)

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gygi, M. P.
Right arrow Articles by Hanson, G. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gygi, M. P.
Right arrow Articles by Hanson, G. R.

Methcathinone: an initial study of its effects on monoaminergic systems

MP Gygi, JW Gibb and GR Hanson

Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, USA.

Methcathinone is a stimulant recently designated a Schedule I drug. Its use and popularity are growing; however, little data are available concerning its neurochemical properties. We investigated the effects of single and multiple doses of methcathinone on dopaminergic and serotonergic systems in the rat. Multiple doses of 30 mg/kg methcathinone caused dramatic decreases in neurochemical parameters associated with both dopaminergic and serotonergic systems in the striatum; corresponding decreases also occurred in serotonergic parameters in hippocampus and frontal cortex. These reductions in enzyme activity and concentrations of transmitters and their metabolites were apparent of 18 and 72 hr after drug administration. In addition, a single dose of methcathinone caused a significant decrease in the serotonergic enzyme activity in the striatum that was evident at 30 min and 2 hr after drug administration. We found that doses of 10 and 20 mg/kg causes no effect on striatal monoaminergic systems; however, doses higher that the 30 mg/kg dose caused significant lethality. In comparison with other stimulants of abuse, methcathinone appears to be most similar to methamphetamine with regard to its effects on monamine systems.

Volume 276, Issue 3, pp. 1066-1072, 03/01/1996
Copyright © 1996 by American Society for Pharmacology and Experimental Therapeutics




This article has been cited by other articles:


Home page
 J. Neurosci.Home page
U. D. McCann, D. F. Wong, F. Yokoi, V. Villemagne, R. F. Dannals, and G. A. Ricaurte
Reduced Striatal Dopamine Transporter Density in Abstinent Methamphetamine and Methcathinone Users: Evidence from Positron Emission Tomography Studies with [11C]WIN-35,428
J. Neurosci., October 15, 1998; 18(20): 8417 - 8422.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
M. P. Gygi, A. E. Fleckenstein, J. W. Gibb, and G. R. Hanson
Role of Endogenous Dopamine in the Neurochemical Deficits Induced by Methcathinone
J. Pharmacol. Exp. Ther., December 1, 1997; 283(3): 1350 - 1355.
[Abstract] [Full Text]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1996 by the American Society for Pharmacology and Experimental Therapeutics.