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A catechol derivative (4-methylcatechol) accelerates the recovery from experimental acrylamide-induced neuropathy

K Saita, T Ohi, Y Hanaoka, S Furukawa, Y Furukawa, K Hayashi and S Matsukura

Department of Internal Medicine, Miyazaki Medical College, Japan.

Acrylamide (ACR) monomer produces neuropathy of the dying-back type and 4-methylcatechol (4-MC) is a potent stimulator of endogenous nerve growth factor synthesis. In the present study, we investigated the efficacy of 4-MC in promoting recovery from experimental ACR neuropathy in rats. Twenty-two Sprague-Dawley rats were made neuropathic by ACR injections. They showed hindlimb paralysis, increment of landing foot spread distance and a statistically significant reduction in motor nerve conduction velocity. After the ACR neuropathy had been established, 12 of the rats were administered 4-MC for 2 weeks, and the other 10 were injected with phosphate-buffered saline alone. 4-MC- administered ACR neuropathy rats showed improvement, i.e., a decrease in landing foot spread distance, increase in motor nerve conduction velocity and increase in nerve growth factor content in the sciatic nerves in comparison with the corresponding values for ACR neuropathy rats given phosphate-buffered saline alone. A decreased number of large myelinated fiber with a reciprocal increase in small myelinated fiber number also was seen in the ACR neuropathy rats; however, this change was ameliorated in part by the administration of 4-MC. Therefore, these findings suggest that 4-MC can accelerate the recovery process clinically, electrophysiologically, biochemically and neuropathologically.

Volume 276, Issue 1, pp. 231-237, 01/01/1996
Copyright © 1996 by American Society for Pharmacology and Experimental Therapeutics




This article has been cited by other articles:


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A. Nitta, M. Ito, H. Fukumitsu, M. Ohmiya, H. Ito, A. Sometani, H. Nomoto, Y. Furukawa, and S. Furukawa
4-Methylcatechol Increases Brain-Derived Neurotrophic Factor Content and mRNA Expression in Cultured Brain Cells and in Rat Brain In Vivo
J. Pharmacol. Exp. Ther., December 1, 1999; 291(3): 1276 - 1283.
[Abstract] [Full Text]


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Copyright © 1996 by the American Society for Pharmacology and Experimental Therapeutics.