JPET Introducing ALZET?ew Model 2006 Pump

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Fekete, Z.
Right arrow Articles by Aviv, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fekete, Z.
Right arrow Articles by Aviv, A.

The endothelin receptor profile in L6 myotubes

Z Fekete, XY Yang, M Kimura and A Aviv

Hypertension Research Center, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, USA.

In this study we characterized the endothelin (ET) receptors of cultured L6 myotubes in order to gain a further insight into the mechanism of the ET effect on skeletal muscle cells. Displacements of 125I-ET-1 by unlabeled ET-1, ET-2 and ET-3 revealed receptors with a high affinity (Kd < 1 nmol/l) to ET-1 and ET-2 and a low affinity (Kd > 100 nmol/l) to ET-3, which suggested the presence of primarily ETA receptors on L6 myotubes. These findings were complemented by displacement binding kinetics, in which the ETA receptor antagonist JKC- 301 was used. More-over, the ET-1-evoked increase in the cytosolic free Ca was blocked by JKC-301 but not by the ETB receptor antagonist IRL- 1038. Collectively, these findings indicate that the ET-mediated response in cultured skeletal muscle cells is through the ETA receptor.

Volume 275, Issue 1, pp. 215-218, 10/01/1995
Copyright © 1995 by American Society for Pharmacology and Experimental Therapeutics




This article has been cited by other articles:


Home page
 Am. J. Respir. Cell Mol. Bio.Home page
Y. Guo, P. Cernacek, A. Giaid, and S. N. A. Hussain
Production of Endothelins by the Ventilatory Muscles in Septic Shock
Am. J. Respir. Cell Mol. Biol., September 1, 1998; 19(3): 470 - 476.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
C. E. Hill, A. Kirton, D. D. Wu, and S. J. Vanner
Role of maxi-K+ channels in endothelin-induced vasoconstriction of mesenteric and submucosal arterioles
Am J Physiol Gastrointest Liver Physiol, November 1, 1997; 273(5): G1087 - G1093.
[Abstract] [Full Text] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1995 by the American Society for Pharmacology and Experimental Therapeutics.