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Journal of Pharmacology And Experimental Therapeutics, Vol. 27, Issue 4, 327-334, 1926
Copyright © 1926 by American Society for Pharmacology and Experimental Therapeutics

IV. THE EFFECT OF SODIUM PHENOBARBITAL AND SOME OTHER BARBITURIC ACID DERIVATIVES UPON THE CORONARY CIRCULATION

CHARLES M. GRUBER 1 and SAMUEL J. ROBERTS 1

1 From the Department of Pharmacology, Washington University Medical School, St. Louis

1. All the barbituric acid derivatives tested, di-ethyl, "barbital," phenyl ethyl, "luminal" sodium phenyl ethyl, "sodium luminal" iso-amyl ethyl "amytal" and iso-propyl allyl "somnifen" in dilute solutions produce coronary vaso-dilatation when injected into the perfusate of an isolated cat or rabbit heart.

2. Concentrated solutions produce variable results, but these we believe to be due in part if not wholly to the change in the pH of the perfusion fluid.

3. Iso-amyl ethyl barbituric acid when injected intravenously in saturated aqueous solutions materially lowers the arterial blood pressure in experimental animals.

Submitted on December 18, 1925






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Copyright © 1926 by the American Society for Pharmacology and Experimental Therapeutics.