JPET

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mousseau, D. D.
Right arrow Articles by Larson, A. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mousseau, D. D.
Right arrow Articles by Larson, A. A.

An antinociceptive effect of capsaicin in the adult mouse mediated by the NH2-terminus of substance P

DD Mousseau, X Sun and AA Larson

Department of Veterinary PathoBiology, University of Minnesota, Saint Paul.

Capsaicin in the adult animal is believed to evoke a massive release of substance P (SP) and a subsequent loss of primary afferent C-fiber activity. Given the antinociceptive effect of SP N-terminal metabolites, the present experiments were designed to compare behavioral and nociceptive responses after treatments with capsaicin or the SP NH2-terminal fragment, SP(1-7), and to determine whether they share a common mechanism of action. When adult mice were tested using the hot-plate assay, 24 hr after intrathecal injections of either capsaicin (0.3-2.6 nmol) or SP(1-7) (22.5 pmol-10 nmol), a dose-related antinociception was observed. The caudally directed biting and scratching behaviors induced by 1 nmol of capsaicin injected intrathecally were also greatly reduced 24 hr after either 2.6 nmol of capsaicin or 10 nmol of SP(1-7). Pretreatment with an antagonist of the NH2-terminus of SP, [D-Pro2,D-Phe7]-SP(1-7), prevented the long-term effects of capsaicin and of SP(1-7) on capsaicin-induced behaviors in our paradigm at doses that the COOH-terminal antagonist of neurokinin activity, [D-Pro2,D-Trp7,9]-SP, did not. The antinociceptive effect of capsaicin in the adult animal is, therefore, mimicked by SP(1-7) and attenuated by [D-Pro2,D-Phe7]-SP(1-7), suggesting that the NH2-terminus of SP and its NH2-terminal metabolites, released in response to capsaicin, may contribute to the mediation of capsaicin's antinociceptive effect.

Volume 268, Issue 2, pp. 785-790, 02/01/1994
Copyright © 1994 by American Society for Pharmacology and Experimental Therapeutics




This article has been cited by other articles:


Home page
 J. Pharmacol. Exp. Ther.Home page
A. A. Larson and K. F. Kitto
Chelation of Zinc in the Extracellular Area of the Spinal Cord, Using Ethylenediaminetetraacetic Acid Disodium-Calcium Salt or Dipicolinic Acid, Inhibits the Antinociceptive Effect of Capsaicin in Adult Mice
J. Pharmacol. Exp. Ther., February 1, 1999; 288(2): 759 - 765.
[Abstract] [Full Text]

Home page
 J. Pharmacol. Exp. Ther.Home page
A. A. Larson and K. F. Kitto
Mutual Antagonism Between Nerve Growth Factor and Substance P N-terminal Activity on Nociceptive Activity in Mice
J. Pharmacol. Exp. Ther., September 1, 1997; 282(3): 1345 - 1350.
[Abstract] [Full Text]

Home page
 J. Pharmacol. Exp. Ther.Home page
R. A. Velázquez, K. F. Kitto, and A. A. Larson

J. Pharmacol. Exp. Ther., June 1, 1997; 281(3): 1231 - 1237.
[Abstract] [Full Text]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1994 by the American Society for Pharmacology and Experimental Therapeutics.