![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
RK Zalups
Division of Basic Medical Sciences, Mercer University School of Medicine, Macon, Georgia.
The effects of the water-soluble chelating agents 2,3-dimercapto-1- propane sulfonate (DMPS) and meso-2,3-dimercaptosuccinic acid (DMSA) on the renal disposition of inorganic mercury were studied in normal and uninephrectomized (NPX) rats injected (i.v.) with a nontoxic 0.5- mumol/kg dose of mercuric chloride (HgCl2). When a 100-mg/kg dose of either DMPS or DMSA was injected (i.p.) 24 and 30 hr after treatment with HgCl2, the renal concentration and burden of inorganic mercury decreased markedly in both normal and NPX rats during the 24 hr after the first dose of the respective chelating agent was administered. Treatment with DMPS was more effective than treatment with DMSA in reducing the renal burden of mercury in both groups of rats. The fall in the renal concentration and burden of mercury in both normal and NPX rats was due primarily to a decrease in the content of mercury in the renal cortex and outer stripe of the outer medulla. However, the decrease in the concentration of inorganic mercury in the outer stripe was significantly greater in NPX rats than in normal rats. Both chelating agents caused urinary excretion of mercury to increase significantly in normal and NPX rats. In association with the increased renal release of mercury in NPX rats, the urinary excretion of mercury per gram of kidney was significantly greater in NPX rats than in normal rats. These data indicate that the renal handling of DMPS and DMSA may be altered significantly after a substantial reduction in renal mass. Findings from the present study also show that treatment with DMPS, but not with DMSA, causes the content of mercury in the liver and cellular fraction of blood to decrease in normal and NPX rats. These findings indicate that there are significant differences in the extrarenal handling of these two chelating agents. The findings in the present study suggest that DMPS and DMSA are very effective agents in reducing the renal (and whole body) burden of inorganic mercury in normal and NPX rats.
This article has been cited by other articles:
|
|
 |
|
  C. C. Bridges, L. Joshee, and R. K. Zalups MRP2 and the DMPS- and DMSA-Mediated Elimination of Mercury in TR- and Control Rats Exposed to Thiol S-Conjugates of Inorganic Mercury Toxicol. Sci., September 1, 2008; 105(1): 211 - 220. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. C. Bridges, L. Joshee, and R. K. Zalups Multidrug Resistance Proteins and the Renal Elimination of Inorganic Mercury Mediated by 2,3-Dimercaptopropane-1-Sulfonic Acid and Meso-2,3-dimercaptosuccinic Acid J. Pharmacol. Exp. Ther., January 1, 2008; 324(1): 383 - 390. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Iglesia-Turino, A. Febrero, O. Jauregui, C. Caldelas, J. L. Araus, and J. Bort Detection and Quantification of Unbound Phytochelatin 2 in Plant Extracts of Brassica napus Grown with Different Levels of Mercury Plant Physiology, October 1, 2006; 142(2): 742 - 749. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Quondamatteo, W. Krick, Y. Hagos, M.-H. Kruger, K. Neubauer-Saile, R. Herken, G. Ramadori, G. Burckhardt, and B. C. Burckhardt Localization of the sulfate/anion exchanger in the rat liver Am J Physiol Gastrointest Liver Physiol, May 1, 2006; 290(5): G1075 - G1081. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. C. Burckhardt, B. Drinkuth, C. Menzel, A. Konig, J. Steffgen, S. H. Wright, and G. Burckhardt The Renal Na+-Dependent Dicarboxylate Transporter, NaDC-3, Translocates Dimethyl- and Disulfhydryl-Compounds and Contributes to Renal Heavy Metal Detoxification J. Am. Soc. Nephrol., November 1, 2002; 13(11): 2628 - 2638. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. A. EL-Safty, M. Gadallah, A. Shafik, and A. E Shouman Effect of mercury vapour exposure on urinary excretion of calcium, zinc and copper: relationship to alterations in functional and structural integrity of the kidney Toxicology and Industrial Health, September 1, 2002; 18(8): 377 - 388. [Abstract] [PDF]
|
|
|
|
|
|
F. Islinger, M. Gekle, and S. H. Wright Interaction of 2,3-Dimercapto-1-propane Sulfonate with the Human Organic Anion Transporter hOAT1 J. Pharmacol. Exp. Ther., November 1, 2001; 299(2): 741 - 747. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. K. Zalups Molecular Interactions with Mercury in the Kidney Pharmacol. Rev., March 1, 2000; 52(1): 113 - 144. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. H. Lash, D. A. Putt, and R. K. Zalups Influence of Exogenous Thiols on Inorganic Mercury-Induced Injury in Renal Proximal and Distal Tubular Cells from Normal and Uninephrectomized Rats J. Pharmacol. Exp. Ther., November 1, 1999; 291(2): 492 - 502. [Abstract] [Full Text]
|
|
|
|
 |
|
 D. Echeverria, H. V. Aposhian, J. S. Woods, N. J. Heyer, M. M. Aposhian, A. C. Bittner JR., R. K. Mahurin, and M. Cianciola Neurobehavioral effects from exposure to dental amalgam Hgo: new distinctions between recent exposure and Hg body burden FASEB J, August 1, 1998; 12(11): 971 - 980. [Abstract] [Full Text]
|
|
|
|
 |
|
 R. K. Zalups, L. D. Parks, V. T. Cannon, and D. W. Barfuss Mechanisms of Action of 2,3-Dimercaptopropane-1-sulfonate and the Transport, Disposition, and Toxicity of Inorganic Mercury in Isolated Perfused Segments of Rabbit Proximal Tubules Mol. Pharmacol., August 1, 1998; 54(2): 353 - 363. [Abstract] [Full Text]
|
|
|
|
|
|
L. H. Lash, D. A. Putt, and R. K. Zalups Role of Extracellular Thiols in Accumulation and Distribution of Inorganic Mercury in Rat Renal Proximal and Distal Tubular Cells J. Pharmacol. Exp. Ther., June 1, 1998; 285(3): 1039 - 1050. [Abstract] [Full Text]
|
|
 |
 |
 |
|
 |
 |
 |
