![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
M Farre, R de la Torre, M Llorente, X Lamas, B Ugena, J Segura and J Cami
Department of Pharmacology and Toxicology, Autonomous University of Barcelona, Spain.
The effects of 100 mg of intranasal cocaine (COC) in acute alcohol intoxication (1 g/kg) was assessed in nine experienced and non- dependent healthy volunteers in a double-blind, controlled, randomized, cross-over clinical trial. Alcohol alone impaired psychomotor performance, whereas COC alone produced subjective effects related to euphoria and well-being, improved the reaction time and increased heart rate and blood pressure. The combination of COC and alcohol induced a nonsignificant decrease in the subjective feelings of drunkeness, an increase in COC-induced euphoria, a significant improvement in alcohol- related changes in psychomotor performance and a marked increase in heart rate. Subjects experienced subjective and performance effects that could be self-interpreted as more pleasant compared to the effects of alcohol alone. When alcohol was given simultaneously, COC plasma levels were higher (possibly as a result of an inhibition of hepatic metabolism of COC produced by alcohol), norcocaine plasma levels almost doubled and cocaethylene was detected in plasma, so that its basic pharmacokinetic profile could be described. The simultaneous use of both drugs produced changes in heart rate and blood pressure that could increase the risk of cardiovascular toxicity associated with the use of COC.
This article has been cited by other articles:
|
|
 |
|
  M. Farre, S. Abanades, P. N. Roset, A. M. Peiro, M. Torrens, B. O'Mathuna, M. Segura, and R. de la Torre Pharmacological Interaction between 3,4-Methylenedioxymethamphetamine (Ecstasy) and Paroxetine: Pharmacological Effects and Pharmacokinetics J. Pharmacol. Exp. Ther., December 1, 2007; 323(3): 954 - 962. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. E. O'Leary, M. Digregorio, and M. Chahine Closing and Inactivation Potentiate the Cocaethylene Inhibition of Cardiac Sodium Channels by Distinct Mechanisms Mol. Pharmacol., December 1, 2003; 64(6): 1575 - 1585. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Riba, M. Valle, G. Urbano, M. Yritia, A. Morte, and M. J. Barbanoj Human Pharmacology of Ayahuasca: Subjective and Cardiovascular Effects, Monoamine Metabolite Excretion, and Pharmacokinetics J. Pharmacol. Exp. Ther., July 1, 2003; 306(1): 73 - 83. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Hernandez-Lopez, M. Farre, P. N. Roset, E. Menoyo, N. Pizarro, J. Ortuno, M. Torrens, J. Cami, and R. de la Torre 3,4-Methylenedioxymethamphetamine (Ecstasy) and Alcohol Interactions in Humans: Psychomotor Performance, Subjective Effects, and Pharmacokinetics J. Pharmacol. Exp. Ther., January 1, 2002; 300(1): 236 - 244. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. E O'Leary Inhibition of HERG potassium channels by cocaethylene: a metabolite of cocaine and ethanol Cardiovasc Res, January 1, 2002; 53(1): 59 - 67. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. E. Lau, F. Ma, D. M. Foster, and J. L. Falk Pharmacokinetic-Pharmacodynamic Modeling of the Psychomotor Stimulant Effect of Cocaine after Intravenous Administration: Timing Performance Deficits J. Pharmacol. Exp. Ther., February 1, 1999; 288(2): 535 - 543. [Abstract] [Full Text]
|
|
|
|
|
|
M. Farré, R. De La Torre, M. L. González, M. T. Terán, P. N. Roset, E. Menoyo, and J. Camí Cocaine and Alcohol Interactions in Humans: Neuroendocrine Effects and Cocaethylene Metabolism J. Pharmacol. Exp. Ther., October 1, 1997; 283(1): 164 - 176. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. A. Hedaya and W.-J. Pan Effect of Alcohol Coadministration on the Plasma and Brain Concentrations of Cocaine in Rats Drug Metab. Dispos., May 1, 1997; 25(5): 647 - 650. [Abstract] [Full Text]
|
|
 |
 |
 |
|
 |
 |
 |
