![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Y Suzuki, Y Matsumura, Y Egi and S Morimoto
Department of Pharmacology, Osaka University of Pharmaceutical Sciences, Japan.
We examined the role of endogenous angiotensin II on renal noradrenergic neurotransmission in anesthetized dogs, using Losartan, a nonpeptide angiotensin II receptor (angiotensin subtype 1) antagonist. The renal nerve stimulation caused a frequency-dependent increase in renal norepinephrine secretion rate. The low frequency renal nerve stimulation (0.5-2.0 Hz) significantly decreased urine flow and urinary excretion of sodium, without affecting renal hemodynamics. The high frequency renal nerve stimulation (2.5-5.0 Hz) produced a more potent antidiuresis and a renal vasoconstriction that resulted in reductions of renal blood flow and glomerular filtration rate. Intrarenal arterial infusion of Losartan (10 and 100 micrograms/kg/min) did not affect the basal levels of norepinephrine secretion rate, although increased urine formation with some renal vasodilation were observed during infusion of the drug. The administration of Losartan had an inhibitory action on the decreased urine formation, renal vasoconstriction and enhanced norepinephrine secretion rate, in response to renal nerve stimulation. Based on these findings, we suggest that endogenous angiotensin II seems to regulate renal noradrenergic neurotransmission by facilitating norepinephrine release, through the prejunctional angiotensin subtype 1 receptor.
This article has been cited by other articles:
|
|
 |
|
  R. G. Evans, S. L. Burke, G. W. Lambert, and G. A. Head Renal responses to acute reflex activation of renal sympathetic nerve activity and renal denervation in secondary hypertension Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2007; 293(3): R1247 - R1256. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. W. Rajapakse, G. A. Eppel, R. E. Widdop, and R. G. Evans ANG II type 2 receptors and neural control of intrarenal blood flow Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2006; 291(6): R1669 - R1676. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. W. Rajapakse, A. K. Sampson, G. A. Eppel, and R. G. Evans Angiotensin II and nitric oxide in neural control of intrarenal blood flow Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2005; 289(3): R745 - R754. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. E. Le Fevre, S.-J. Guild, R. Ramchandra, C. J. Barrett, and S. C. Malpas Role of Angiotensin II in the Neural Control of Renal Function Hypertension, March 1, 2003; 41(3): 583 - 591. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Yamasaki, I. Tamai, and Y. Matsumura Activation of histamine H3 receptors inhibits renal noradrenergic neurotransmission in anesthetized dogs Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2001; 280(5): R1450 - R1456. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. M. Gironacci, M. Vatta, M. Rodriguez-Fermepin, B. E. Fernandez, and C. Pena Angiotensin-(1-7) Reduces Norepinephrine Release Through a Nitric Oxide Mechanism in Rat Hypothalamus Hypertension, June 1, 2000; 35(6): 1248 - 1252. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X.-H. Jin, Z.-Q. Wang, H. M. Siragy, R. L. Guerrant, and R. M. Carey Regulation of jejunal sodium and water absorption by angiotensin subtype receptors Am J Physiol Regulatory Integrative Comp Physiol, August 1, 1998; 275(2): R515 - R523. [Abstract] [Full Text] [PDF]
|
|
 |
 |
 |
|
 |
 |
 |
