JPET Introducing ALZET?ew Model 2006 Pump

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow A correction has been published
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sandberg, J. A.
Right arrow Articles by Olsen, G. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sandberg, J. A.
Right arrow Articles by Olsen, G. D.

Cocaine and metabolite concentrations in the fetal guinea pig after chronic maternal cocaine administration [published erratum appears in J Pharmacol Exp Ther 1992 Jun;261(3):1290]

JA Sandberg and GD Olsen

Department of Pharmacology, School of Medicine, Oregon Health Sciences University, Portland.

To determine the disposition of cocaine (COC) and metabolites after chronic COC exposure in the late gestation guinea pig, six time-bred Dunkin-Hartley guinea pigs were given 10 daily 6 mg/kg COC s.c. injections from day 50 of gestation. Maternal blood and urine, fetal cord blood, and brain and amniotic fluid were collected 1 hr after the last injection. There was no difference between maternal and fetal plasma COC concentrations. This may be due to the combined effect of lower protein binding and ion trapping of COC in the fetus. Benzoylecgonine was higher in maternal plasma, but benzoylnorecgonine was higher in fetal plasma. COC brain-to-plasma ratios were similar in the dam and fetus. Benzoylecgonine was the only metabolite that could be detected in the brain, but levels were too low to quantitate. COC accumulated 3 to 4 times plasma concentrations in the amniotic fluid and was directly proportional to fetal plasma COC concentrations. Benzoylnorecgonine in amniotic fluid accumulated to 2 times fetal plasma levels. The in vitro half-life of COC in amniotic fluid was 30 times longer than plasma elimination half-life in vivo. The high level and long duration of COC in amniotic fluid serve as a reservoir for prolonged fetal COC exposure.

Volume 260, Issue 2, pp. 587-591, 02/01/1992
Copyright © 1992 by American Society for Pharmacology and Experimental Therapeutics




This article has been cited by other articles:


Home page
 Drug Metab. Dispos.Home page
L. M. Iwamoto, C. M. Moore, N. Fujiwara, M. J. Christ, D. M. Gries, and K. T. Nakamura
m-Hydroxy Benzoylecgonine Recovery in Fetal Guinea Pigs
Drug Metab. Dispos., March 1, 2000; 28(3): 335 - 338.
[Abstract] [Full Text] [PDF]

Home page
 Reproductive SciencesHome page
T. Downs, J. Padbury, L. Blount, K. Kashiwai, and K. Chan
Ovine Fetal-Placental Cocaine Pharmacokinetics During Continuous Cocaine Infusion
Reproductive Sciences, July 1, 1996; 3(4): 185 - 190.
[Abstract] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1992 by the American Society for Pharmacology and Experimental Therapeutics.