JPET

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by HOLMES, E. G.
Right arrow Search for Related Content
PubMed
Right arrow Articles by HOLMES, E. G.
Journal of Pharmacology And Experimental Therapeutics, Vol. 26, Issue 4, 297-314, 1925
Copyright © 1925 by American Society for Pharmacology and Experimental Therapeutics

A CONTRIBUTION TO THE STUDY OF THE METABOLISM OF SALICYLIC ACID

E. G. HOLMES 1

1 From the Department of Physiology, St. Bartholomew's Hospital Medical College, and the Biochemical Laboratory, Cambridge

1. After the ingestion of salicylates by a normal individual on a mixed diet, salicyluric acid was isolated from the urine, and identified. The identification rested on solubility, amino and total nitrogen content, which were satisfactory, and melting point, which was identical with a pure specimen of synthetic salicyluric acid.

2. For doses of sodium salicylate of from 2 to 5 grams, the salicylic/salicyluric ratio is constant at the value of .40/60.

3. This ratio, after the ingestion of 1.5 grams of synthetic salicyluric acid, reaches the value of 8/92.

4. The distillation method for the estimation of total salicyl in urine, described by Hanzlik, is not satisfactory when solutions of pure salicyluric acid in urine are employed.

5. No evidence has been found for the destruction of salicylic acid in the body.

6. Under the conditions of these experiments, no salicyl-glycuronic compound was excreted.

Submitted on May 1, 1925






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1925 by the American Society for Pharmacology and Experimental Therapeutics.