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Effects of sympathetic activation on plasma renin activity in the developing rat

RF Kirby and AK Johnson

Department of Psychology, University of Iowa, Iowa City.

The present experiments studied the ontogeny of sympathetic control of the renin-angiotensin system by using pharmacological agents, which act at different levels of the sympathetic axis, to increase plasma renin activity (PRA) during the preweanling period in Sprague-Dawley rats. The selective beta-1 adrenoceptor agonist, prenalterol, produced age- and dose-dependent PRA increases. In 5- and 10-day-old animals, prenalterol treatment produced minimal stimulation of PRA and the dose- response curve was essentially flat. In contrast, greater PRA responses to increasing doses of prenalterol were found in 15- and 20-day-old animals. The PRA response to tyramine, which causes norepinephrine release from postganglionic sympathetic fibers, gradually increased between 5 and 20 postnatal days of age, first producing significant stimulation on day 15. Centrally mediated sympathetic activation with yohimbine also produced age-dependent stimulation of PRA that was comparable to the increases produced by tyramine between postnatal days 10 and 20. However, in contrast to tyramine, yohimbine produced a significant increase in PRA on postnatal day 5. The present results suggest that functional sympathetic control of the renin-angiotensin system matures during the second to third postnatal week in the Sprague- Dawley rat, and this may be related to the development of beta-1 adrenoceptors in the kidney that regulate renin release.

Volume 253, Issue 1, pp. 152-157, 04/01/1990
Copyright © 1990 by American Society for Pharmacology and Experimental Therapeutics




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Copyright © 1990 by the American Society for Pharmacology and Experimental Therapeutics.