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Effect of dose on nicotine's reinforcing, withdrawal-suppression and self-reported effects

JR Hughes, SW Gust, RM Keenan and JW Fenwick

Department of Psychiatry, University of Vermont, Burlington.

Seventy-eight smokers trying to quit were randomly assigned to 0-, 0.5- , 2- and 4-mg doses of nicotine gum and tracked for 9 months. In the 1st week of abstinence, self-administration of gum did not differ by dose (4 mg = 2 mg = 0.5 mg = 0 mg). Higher doses did not more effectively suppress withdrawal than lower doses nor induce more accurate nicotine identification (4 mg = 2 mg = 0.5 mg greater than 0 mg). Higher doses slightly increased ratings of adverse effects in the 1st week (4 mg greater than 2 mg greater than 0.5 mg greater than 0 mg). Over the next 6 months, the two higher doses appeared to support more gum self-administration than the two lower doses (4 mg = 2 mg greater than 0.5 mg = 0 mg) in the subsample of long-term quitters (n = 20). Our results suggest the dose-response curves differ for nicotine gum's reinforcing, withdrawal-suppression and self-reported effects.

Volume 252, Issue 3, pp. 1175-1183, 03/01/1990
Copyright © 1990 by American Society for Pharmacology and Experimental Therapeutics




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