![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
G Johnson , PS Tsao, D Mulloy and AM Lefer
Department of Physiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania.
The effects of acidified sodium nitrite (NaNO2) which releases nitric oxide, a substance which is thought to be indistinguishable from endothelium-derived relaxing factor, were investigated in a 6-h model of myocardial ischemia (MI) with reperfusion in open-chest, anesthetized cats. Acidified NaNO2 (12.5-50 mmol/kg/hr) was infused i.v., starting 30 min postocclusion followed by reperfusion 1 hr later, in cats subjected to MI by occlusion of the left anterior descending coronary artery. Acidified NaNO2 infusion (25 and 50 mmol/kg/hr) resulted in significantly lower plasma creatine kinase activities at every time beyond 1 hr for the MI + vehicle group, and was not significantly different when compared to sham MI + NaNO2 controls. The areas at risk expressed as percentage of the total left ventricular weights were not significantly different between the MI + vehicle and MI + acidified NaNO2 groups. However, the necrotic area expressed as a percentage of the myocardial area at risk was significantly lower in the 25 and 50 mmol/kg/hr NaNO2-treated cats. Cardiac myeloperoxidase activities indicated that significantly fewer neutrophils were attracted to the ischemic zone of the NaNO2-treated MI cats when compared to the vehicle-infused MI cats. Acidified NaNO2 significantly inhibited platelet aggregation in a dose-dependent manner in cat platelet-rich plasma. Thus, acidified NaNO2 exerts a significant protective action during ischemia and reperfusion injury, which suggests that endothelium-derived relaxing factor has a cardioprotective effect in MI.
This article has been cited by other articles:
|
|
 |
|
  J. W. Elrod, J. J.M. Greer, N. S. Bryan, W. Langston, J. F. Szot, H. Gebregzlabher, S. Janssens, M. Feelisch, and D. J. Lefer Cardiomyocyte-Specific Overexpression of NO Synthase-3 Protects Against Myocardial Ischemia-Reperfusion Injury Arterioscler. Thromb. Vasc. Biol., July 1, 2006; 26(7): 1517 - 1523. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Webb, R. Bond, P. McLean, R. Uppal, N. Benjamin, and A. Ahluwalia Reduction of nitrite to nitric oxide during ischemia protects against myocardial ischemia-reperfusion damage PNAS, September 14, 2004; 101(37): 13683 - 13688. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. Lang, P. J. McArdle, P. J. O'Reilly, and S. Matalon Oxidant-Antioxidant Balance in Acute Lung Injury Chest, December 1, 2002; 122(6_suppl): 314S - 320S. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. E. Jordan, Z.-Q. Zhao, and J. Vinten-Johansen The role of neutrophils in myocardial ischemia-reperfusion injury Cardiovasc Res, September 1, 1999; 43(4): 860 - 878. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Okazaki, K. Komori, K. Kawasaki, D. Eguchi, M. Ishida, and K. Sugimachi L-Arginine inhibits smooth muscle cell proliferation of vein graft intimal thickness in hypercholesterolemic rabbits Cardiovasc Res, December 1, 1997; 36(3): 429 - 436. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-H. Liu, X.-P. Yang, V. G. Sharov, D. H. Sigmon, H. N. Sabbah, and O. A. Carretero Paracrine Systems in the Cardioprotective Effect of Angiotensin-Converting Enzyme Inhibitors on Myocardial Ischemia/Reperfusion Injury in Rats Hypertension, January 1, 1996; 27(1): 7 - 13. [Abstract] [Full Text]
|
|
|
|
 |
|
 A. M. Lefer Attenuation of Myocardial Ischemia-Reperfusion Injury With Nitric Oxide Replacement Therapy Ann. Thorac. Surg., September 1, 1995; 60(3): 847 - 851. [Abstract] [Full Text]
|
|
|
|
 |
|
 K. Nakanishi, Z.-Q. Zhao, J. Vinten-Johansen, D. A. Hudspeth, D. S. McGee, and J. W. Hammon Jr. Blood cardioplegia enhanced with nitric oxide donor SPM-5185 counteracts postischemic endothelial and ventricular dysfunction J. Thorac. Cardiovasc. Surg., June 1, 1995; 109(6): 1146 - 1154. [Abstract] [Full Text]
|
|
|
|
 |
|
 P. R. Hansen Role of Neutrophils in Myocardial Ischemia and Reperfusion Circulation, March 15, 1995; 91(6): 1872 - 1885. [Abstract] [Full Text]
|
|
|
|
|
|
R. G. Woolfson, V. C. Patel, G. H. Neild, and D. M. Yellon Inhibition of Nitric Oxide Synthesis Reduces Infarct Size by an Adenosine-Dependent Mechanism Circulation, March 1, 1995; 91(5): 1545 - 1551. [Abstract] [Full Text]
|
|
|
|
|
|
Y. Naka, N. C. Chowdhury, M. C. Oz, C. R. Smith, O. J. Yano, R. E. Michler, D. M. Stern, and D. J. Pinsky Nitroglycerin maintains graft vascular homeostasis and enhances preservation in an orthotopic rat lung transplant model J. Thorac. Cardiovasc. Surg., February 1, 1995; 109(2): 206 - 211. [Abstract] [Full Text]
|
|
 |
 |
 |
|
 |
 |
 |
