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Antiangiogenic action of heparin plus cortisone is associated with decreased collagenous protein synthesis in the chick chorioallantoic membrane system

ME Maragoudakis, M Sarmonika and M Panoutsacopoulou

Department of Pharmacology, University of Patras Medical School, Greece.

In the chick chorioallantoic membrane system heparin plus cortisone caused a marked depression in the rate of collagenous protein biosynthesis in vivo during inhibition of angiogenesis. This suggests that monitoring the rate of collagenous protein biosynthesis in the chick chorioallantoic membrane system can be used as a quantitative method for evaluating angiogenesis inhibitors.

Volume 251, Issue 2, pp. 679-682, 11/01/1989
Copyright © 1989 by American Society for Pharmacology and Experimental Therapeutics




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Copyright © 1989 by the American Society for Pharmacology and Experimental Therapeutics.