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Correlation between the inhibitory effect on catecholaminergic ventrolateral medullary neurons and the hypotension evoked by clonidine: a voltammetric approach

E Tibirica, C Mermet, J Feldman, F Gonon and P Bousquet

Laboratoire de Pharmacologie Cardiovasculaire et Renale, Faculte de Medecine, Universite Louis Pasteur, Strasbourg, France.

Neuronal activity was monitored in vivo by differential voltammetry, an electrochemical technique measuring the metabolism of catecholamines. This technique was used to determine the influence of low doses of clonidine (starting from 2 micrograms/kg i.v.) on the activity of the catecholaminergic neurons of the nucleus reticularis lateralis region, site of its hypotensive action, and of the locus ceruleus, which is involved in its sedative effect. There was a correlation between the hypotensive effect of low doses of clonidine (2, 5 and 10 micrograms/kg i.v.) and the decrease of the neuronal metabolic activity within the ventrolateral medulla, whereas only higher doses of clonidine (50 micrograms/kg i.v.) decreased the metabolic activity in the locus ceruleus. Thus, we demonstrate in vivo differences in sensitivity toward the same drug of two different neuronal structures that are involved in the regulation of the cardiovascular and wakefulness functions, respectively. The present study also shows that clonidine has a preferential action on a medulla oblongata region that contains imidazoline-preferring receptors, namely the nucleus reticularis lateralis region, rather than on the locus ceruleus region, that contains mainly alpha-2 adrenoceptors.

Volume 250, Issue 2, pp. 642-647, 08/01/1989
Copyright © 1989 by American Society for Pharmacology and Experimental Therapeutics




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