THE EFFECT OF THE ADMINISTRATION OF DESICCATED RED BONE MARROW AND SPLEEN ON THE RESISTANCE OF ERYTHROCYTES TO HYPOTONIC SALINE SOLUTIONS IN DOGS

¹ From the Pharmacological Laboratory of the University of Wisconsin

The administration of desiccated spleen and red bone marrow combined in equal proportions by weight to dogs is followed in twenty-four to forty-eight hours by an increased osmotic resistance of erythrocytes to hypotonic saline solutions. This either precedes or coincides with the marked rise in the total number of red cells observed after such administration. Evidence is thus offered in support in support of the hypothesis that an augmented resistance of the erythrocytes, as well as the influx of reticulocytes, may be a factor in contributing to this rise.