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Journal of Pharmacology And Experimental Therapeutics, Vol. 25, Issue 3, 219-234, 1925
Copyright © 1925 by American Society for Pharmacology and Experimental Therapeutics

I. THE EFFECT OF PHENOBARBITAL (LUMINAL) AND SODIUM PHENOBARBITAL (LUMINAL-SODIUM) UPON BLOOD PRESSURE AND RESPIRATION

CHARLES M. GRUBER 1 and ROY F. BASKETT 1

1 From the Department of Pharmacology, Washington University, School of Medicine, St. Louis, Missouri

1. Administration of sodium phenobarbital and phenobarbital in moderate doses (0.05 to 0.5 gram) caused a fall in blood pressure in 162 out of 164 cases.

2. Sodium phenobarbital in small and moderate doses caused acceleration of respiration with decreased depth in most instances. In 1 case a slowed respiration only was noted.

3. Small and moderate doses of sodium phenobarbital usually cause, after the temporary acceleration a slowed rate and increased depth of respiration.

4. Large doses of sodium phenobarbital and phenobarbital cause paralysis of respiration. The heart continues to beat for some seconds, even minutes, after cessation in respiration.

Submitted on August 29, 1924






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Copyright © 1925 by the American Society for Pharmacology and Experimental Therapeutics.