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Uptake and hormonally induced hydrolysis of [3H]phosphatidyl choline in the isolated rabbit heart

MT Weis and KU Malik

Department of Pharmacology, University of Tennessee, Memphis.

Tritiated phosphatidyl choline (1-palmitoyl,2-[3H]palmitoyl or 1- stearoyl,2-[3H]arachidonyl) is taken up unchanged by the isolated perfused rabbit heart. Isoproterenol, vasopressin or A23187 enhanced the output of tritium in these hearts, whereas bradykinin, angiotensin II or acetylcholine had no effect. These data demonstrate that [3H]phosphatidyl choline is incorporated directly into a phospholipid pool that is accessible to some, but not all, hormonally stimulated lipases. In hearts labeled with 1-stearoyl,2-[3H]arachidonyl phosphatidyl choline, the radioactivity released by isoproterenol consisted of free fatty acid and lysophosphatidyl choline, indicating that isoproterenol stimulates both phospholipase(s) A1 and A2. Vasopressin and A23187 increased the release of free fatty acid, but not lysophosphatidyl choline, suggesting that these agents stimulate only phospholipase A2.

Volume 248, Issue 2, pp. 614-620, 02/01/1989
Copyright © 1989 by American Society for Pharmacology and Experimental Therapeutics




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