![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
CC Felder, PA Jose and J Axelrod
Section on Pharmacology, National Institute of Mental Health, Bethesda, Maryland.
Dopamine-1 (DA-1) receptors have been found in renal tubular membranes which stimulate both adenylate cyclase and phospholipase-C activity. In renal cortical plasma membrane preparations the DA-1 agonist SKF 82526, forskolin and NaF stimulated adenylate cyclase activity. 2',5'- dideoxyadenosine inhibited basal and DA-1 agonist stimulated adenylate cyclase activity. Forskolin, NaF, dibutyryl-cyclic AMP and 2',5'- dideoxyadenosine had no effect on basal or DA-1 agonist stimulated phospholipase-C activity in these membranes. These studies indicate that DA-1 agonist stimulates adenylate cyclase and phospholipase-C activities independently. Phospholipase-C activity was also increased by the nonhydrolyzable GTP analog, guanosine-5'-O-(3-thiophosphate). When DA-1 agonist and guanosine-5'-O-(3-thiophosphate) were added together there was a slight but significant increase in phospholipase-C activity. This increase was inhibited in the presence of guanosine-5'-O- (2-thiodiphosphate). DA-1 stimulated phospholipase-C activity was found to be insensitive to both cholera and pertussis toxins. The present studies indicate a cyclic AMP independent transduction pathway for DA-1 receptor mediated through a guanine nucleotide regulatory protein associated phospholipase-C.
This article has been cited by other articles:
|
|
 |
|
  Z. Li, C. Yu, Y. Han, H. Ren, W. Shi, C. Fu, D. He, L. Huang, C. Yang, X. Wang, et al. Inhibitory effect of D1-like and D3 dopamine receptors on norepinephrine-induced proliferation in vascular smooth muscle cells Am J Physiol Heart Circ Physiol, June 1, 2008; 294(6): H2761 - H2768. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Zeng, I. Armando, Y. Luo, G. M. Eisner, R. A. Felder, and P. A. Jose Dysregulation of dopamine-dependent mechanisms as a determinant of hypertension: studies in dopamine receptor knockout mice Am J Physiol Heart Circ Physiol, February 1, 2008; 294(2): H551 - H569. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. A. Banday and M. F. Lokhandwala Oxidative stress reduces renal dopamine D1 receptor-Gq/11{alpha} G protein-phospholipase C signaling involving G protein-coupled receptor kinase 2 Am J Physiol Renal Physiol, July 1, 2007; 293(1): F306 - F315. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Chen, J. D. Bohanick, M. Nishihara, J. K. Seamans, and C. R. Yang Dopamine D1/5 Receptor-Mediated Long-Term Potentiation of Intrinsic Excitability in Rat Prefrontal Cortical Neurons: Ca2+-Dependent Intracellular Signaling J Neurophysiol, March 1, 2007; 97(3): 2448 - 2464. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Yang, L. D. Asico, P. Yu, Z. Wang, J. E. Jones, R.-k. Bai, D. R. Sibley, R. A. Felder, and P. A. Jose D5 dopamine receptor regulation of phospholipase D Am J Physiol Heart Circ Physiol, January 1, 2005; 288(1): H55 - H61. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Zhen, S. Goswami, S. A. Abdali, M. Gil, K. Bakshi, and E. Friedman Regulation of Cyclin-Dependent Kinase 5 and Calcium/Calmodulin-Dependent Protein Kinase II by Phosphatidylinositol-Linked Dopamine Receptor in Rat Brain Mol. Pharmacol., December 1, 2004; 66(6): 1500 - 1507. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Zeng, H. Sanada, H. Watanabe, G. M. Eisner, R. A. Felder, and P. A. Jose Functional genomics of the dopaminergic system in hypertension Physiol Genomics, November 17, 2004; 19(3): 233 - 246. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. A. Banday, M. Asghar, T. Hussain, and M. F. Lokhandwala Dopamine-Mediated Inhibition of Renal Na,K-ATPase Is Reduced by Insulin Hypertension, June 1, 2003; 41(6): 1353 - 1358. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Zheng, P. Yu, C. Zeng, Z. Wang, Z. Yang, P. M. Andrews, R. A. Felder, and P. A. Jose G{alpha}12- and G{alpha}13-Protein Subunit Linkage of D5 Dopamine Receptors in the Nephron Hypertension, March 1, 2003; 41(3): 604 - 610. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Hussain and M. F. Lokhandwala Renal Dopamine Receptors and Hypertension Experimental Biology and Medicine, February 1, 2003; 228(2): 134 - 142. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. X. Li, J. Xu, S. Zheng, F. E. Albrecht, J. E. Robillard, G. M. Eisner, and P. A. Jose D1 dopamine receptor regulation of NHE3 during development in spontaneously hypertensive rats Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2001; 280(6): R1650 - R1656. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. A. Gorelova and C. R. Yang Dopamine D1/D5 Receptor Activation Modulates a Persistent Sodium Current in Rat Prefrontal Cortical Neurons In Vitro J Neurophysiol, July 1, 2000; 84(1): 75 - 87. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Vieira-Coelho, T. Hussain, V. Kansra, M. P. Serrao, J. T. Guimaraes, M. Pestana, P. Soares-da-Silva, and M. F. Lokhandwala Aging, High Salt Intake, and Renal Dopaminergic Activity in Fischer 344 Rats Hypertension, October 1, 1999; 34(4): 666 - 672. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. A. Jose, L. D. Asico, G. M. Eisner, F. Pocchiari, C. Semeraro, and R. A. Felder Effects of costimulation of dopamine D1- and D2-like receptors on renal function Am J Physiol Regulatory Integrative Comp Physiol, October 1, 1998; 275(4): R986 - R994. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Hussain and M. F. Lokhandwala Renal Dopamine Receptor Function in Hypertension Hypertension, August 1, 1998; 32(2): 187 - 197. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. MISSALE, S. R. NASH, S. W. ROBINSON, M. JABER, and M. G. CARON Dopamine Receptors: From Structure to Function Physiol Rev, January 1, 1998; 78(1): 189 - 225. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. L. BARNARD, W. G. OLIVERA, D. M. RUTSCHMAN, A. M. BERTORELLO, A. I. KATZ, and J. I. SZNAJDER Dopamine Stimulates Sodium Transport and Liquid Clearance in Rat Lung Epithelium Am. J. Respir. Crit. Care Med., September 1, 1997; 156(3): 709 - 714. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Friedman, L.-Q. Jin, G.-P. Cai, T. R. Hollon, J. Drago, D. R. Sibley, and H.-Y. Wang D1-like Dopaminergic Activation of Phosphoinositide Hydrolysis Is Independent of D1A Dopamine Receptors: Evidence from D1A Knockout Mice Mol. Pharmacol., January 1, 1997; 51(1): 6 - 11. [Abstract] [Full Text]
|
|
|
|
 |
|
 P.-Y. Yu, GilbertM. Eisner, I. Yamaguchi, M.M. Mouradian, RobinA. Felder, and PedroA. Jose Dopamine D1A Receptor Regulation of Phospholipase C Isoform J. Biol. Chem., August 9, 1996; 271(32): 19503 - 19508. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kimura, B. H. White, and A. Sidhu Coupling of Human D-1 Dopamine Receptors to Different Guanine Nucleotide Binding Proteins J. Biol. Chem., June 16, 1995; 270(24): 14672 - 14678. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Gomes and P. Soares-da-Silva Role of cAMP-PKA-PLC signaling cascade on dopamine-induced PKC-mediated inhibition of renal Na+-K+-ATPase activity Am J Physiol Renal Physiol, June 1, 2002; 282(6): F1084 - F1096. [Abstract] [Full Text] [PDF]
|
|
 |
 |
 |
|
 |
 |
 |
