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Pharmacological characterization of muscarinic receptors mediating inhibition of adenylate cyclase activity in the rat retina

ZX Qu, R Fertel, NH Neff and M Hadjiconstantinou

Department of Pharmacology, Ohio State University College of Medicine, Columbus.

Incubation of the rat retina with acetylcholine resulted in about a 20 to 30% decrease of basal cyclic AMP accumulation. Oxotremorine, arecoline, [4-hydroxy-2-butynyl]trimethylammonium chloride, m- chlorocarbanilate and carbachol also inhibited cyclic AMP accumulation. Nicotine had no effect. The response was blocked by atropine and pirenzepine but not gallamine. Intraocular injection of pertussis toxin 72 hr before testing also blocked the response to acetylcholine. The presence of forskolin exaggerated the response to acetylcholine. Intraocular injection of the cholinotoxin AF64A resulted in apparent supersensitivity of the response to acetylcholine. Our results suggest that rat retina contains muscarinic M1 receptors that are coupled negatively to adenylate cyclase.

Volume 246, Issue 3, pp. 839-842, 09/01/1988
Copyright © 1988 by American Society for Pharmacology and Experimental Therapeutics






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Copyright © 1988 by the American Society for Pharmacology and Experimental Therapeutics.