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*Compound via MeSH
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*DIMERCAPROL
*MERCURIC CHLORIDE
*MERCURY COMPOUNDS
*MERCURY, ELEMENTAL
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*Mercury

Estimation of mercury burdens in rats by chelation with dimercaptopropane sulfonate

MG Cherian, EF Miles, TW Clarkson and C Cox

Department of Pathology, University of Western Ontario, London, Canada.

The chelation of mercury by 2,3-dimercaptopropane-1-sulfonate (DMPS) and its usefulness in the estimation of mercury burdens was investigated by exposing male, Sprague-Dawley rats to 203HgCl2 (0.1-2 mg of Hg per kg i.p.) or 203Hg vapor (0.5-2.0 mg of Hg per m3). DMPS (0.2-2.0 mmol/kg) was injected i.p. at times ranging from 1 to 38 days after exposure to the mercurial. Urine and feces were collected for 24 hr before and after DMPS treatment. Whole body mercury levels, tissue levels and excretion of mercury were measured by radioactivity counting. After DMPS treatment there was a significant decrease of whole body mercury levels and an increase in urinary excretion. The increase in urinary excretion was directly proportional to the whole body burden of mercury at the time of dosing with DMPS in animals dosed with HgCl2 and exposed to mercury vapor. Furthermore, the increase in urinary excretion induced by DMPS was almost equal to the amount of mercury lost from the kidneys.

Volume 245, Issue 2, pp. 479-484, 05/01/1988
Copyright © 1988 by American Society for Pharmacology and Experimental Therapeutics




This article has been cited by other articles:


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S. D. Pingree, P. L. Simmonds, and J. S. Woods
Effects of 2,3-Dimercapto-1-propanesulfonic Acid (DMPS) on Tissue and Urine Mercury Levels following Prolonged Methylmercury Exposure in Rats
Toxicol. Sci., June 1, 2001; 61(2): 224 - 233.
[Abstract] [Full Text] [PDF]


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