![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
S Wigdor and GL Wilcox
The relative importance of descending serotonergic and noradrenergic pathways to the antinociceptive action of supraspinally and systemically administered morphine sulfate, and to the antinociceptive synergism observed between spinally and supraspinally administered morphine was examined in mice. Morphine administered i.c.v., intrathecally (i.t.), s.c. or i.t. + i.c.v. produced a dose-dependent antinociceptive response, as measured by the tail-flick test. The dose- response curve for morphine (i.c.v.) was shifted significantly to the right by equal i.t. doses of methysergide or phentolamine. However, the most pronounced shift to the right was caused by i.t. administration of the selective alpha-2 antagonist yohimbine. Administration of a subantinociceptive dose of morphine (i.t.) along with morphine (i.c.v.) shifted the dose-response curve for morphine (i.c.v.) 6-fold to the left. The resulting dose-response curve for morphine (i.c.v.) was shifted to the right more by phentolamine (i.t.) than by methysergide (i.t.). Similarly, the dose-response curve for morphine (s.c.) was shifted more to the right by phentolamine (i.t.) than by methysergide (i.t.). These results suggest that the descending noradrenergic system, more than the serotonergic system, may be an important component in spinal/supraspinal interactive mechanisms that may mediate the antinociceptive action of systemically administered morphine.
This article has been cited by other articles:
|
|
 |
|
  Y. Ji, A. Z. Murphy, and R. J. Traub Sex differences in morphine-induced analgesia of visceral pain are supraspinally and peripherally mediated Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2006; 291(2): R307 - R314. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-P. Chen, S.-R. Chen, and H.-L. Pan Systemic Morphine Inhibits Dorsal Horn Projection Neurons through Spinal Cholinergic System Independent of Descending Pathways J. Pharmacol. Exp. Ther., August 1, 2005; 314(2): 611 - 617. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. K. S. Ong, R. A. Seymour, and J. M.-H. Tan Sedation with Midazolam Leads to Reduced Pain After Dental Surgery Anesth. Analg., May 1, 2004; 98(5): 1289 - 1293. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. A. Jordan, I. Gomes, C Rios, J. Filipovska, and L. A. Devi Functional Interactions between {micro} Opioid and {alpha}2A-Adrenergic Receptors Mol. Pharmacol., December 1, 2003; 64(6): 1317 - 1324. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Fairbanks, L. S. Stone, K. F. Kitto, H. O. Nguyen, I. J. Posthumus, and G. L. Wilcox alpha 2C-Adrenergic Receptors Mediate Spinal Analgesia and Adrenergic-Opioid Synergy J. Pharmacol. Exp. Ther., January 1, 2002; 300(1): 282 - 290. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Tallarida Drug Synergism: Its Detection and Applications J. Pharmacol. Exp. Ther., September 1, 2001; 298(3): 865 - 872. [Abstract] [Full Text]
|
|
|
|
 |
|
 J. J. Rady, B. B. Holmes, P. S. Portoghese, and J. M. Fujimoto Morphine Tolerance in Mice Changes Response of Heroin from {micro} to {delta} Opioid Receptors Experimental Biology and Medicine, June 1, 2000; 224(2): 93 - 101. [Abstract] [Full Text]
|
|
|
|
|
|
C. A. Fairbanks and G. L. Wilcox Moxonidine, a Selective alpha 2-Adrenergic and Imidazoline Receptor Agonist, Produces Spinal Antinociception in Mice J. Pharmacol. Exp. Ther., July 1, 1999; 290(1): 403 - 412. [Abstract] [Full Text]
|
|
|
|
|
|
C. A. Fairbanks and G. L. Wilcox Spinal Antinociceptive Synergism between Morphine and Clonidine Persists in Mice Made Acutely or Chronically Tolerant to Morphine J. Pharmacol. Exp. Ther., March 1, 1999; 288(3): 1107 - 1116. [Abstract] [Full Text]
|
|
|
|
|
|
C. Courteix, P. Bourget, F. Caussade, M. Bardin, F. Coudore, J. Fialip, and A. Eschalier Is the Reduced Efficacy of Morphine in Diabetic Rats Caused by Alterations of Opiate Receptors or of Morphine Pharmacokinetics? J. Pharmacol. Exp. Ther., April 1, 1998; 285(1): 63 - 70. [Abstract] [Full Text]
|
|
|
|
 |
|
 K. Gao, D. O. Chen, J. R. Genzen, and P. Mason Activation of Serotonergic Neurons in the Raphe Magnus Is Not Necessary for Morphine Analgesia J. Neurosci., March 1, 1998; 18(5): 1860 - 1868. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. S. Stone, L. B. MacMillan, K. F. Kitto, L. E. Limbird, and G. L. Wilcox The alpha 2a Adrenergic Receptor Subtype Mediates Spinal Analgesia Evoked by alpha 2 Agonists and Is Necessary for Spinal Adrenergic-Opioid Synergy J. Neurosci., September 15, 1997; 17(18): 7157 - 7165. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. W. Suh, D. K. Song, S. R. Choi, S. O. Huh, and Y. H. Kim Differential Effects of omega -Conotoxin GVIA, Nimodipine, Calmidazolium and KN-62 Injected Intrathecally on the Antinociception Induced by beta -Endorphin, Morphine and [D-Ala2,N-MePhe4,Gly-ol5]-enkephalin Administered Intracerebroventricularly in the Mouse J. Pharmacol. Exp. Ther., August 1, 1997; 282(2): 961 - 966. [Abstract] [Full Text]
|
|
 |
 |
 |
|
 |
 |
 |
