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Comparison of opioid self-injection and disruption of schedule- controlled performance in the baboon

SE Lukas, JV Brady and RR Griffiths

Eight opioid agonist, mixed agonist/antagonist or antagonist compounds were compared in baboons. In the first experiment, i.v. drug self- injection procedures involved a fixed-ratio schedule with a 3 hr time- out after each injection. Doses of a test drug were substituted for cocaine for 12 or 15 days. Codeine, morphine, butorphanol, nalbuphine and pentazocine all maintained self-injection above vehicle control levels. These compounds differed in their relative potencies, and morphine did not maintain maximal drug self-injection rates. Buprenorphine maintained self-injection in only one of four baboons, and SKF-10,047 and naloxone did not maintain self-injection. In a second experiment, another group of baboons responded on a fixed-ratio 50 schedule of food pellet delivery. Intravenous injections were given 30 min before test sessions that lasted 30 min. All eight drugs produced dose-related decreases in response rates, and the buprenorphine dose-response curve was more shallow and not parallel to the others. Comparison across experiments suggested that the failure of morphine to maintain maximal self-injection rates is due to its relatively high potency in suppressing schedule-controlled performance. The results of this study confirm those of previous studies demonstrating that opioids with morphine-like subjective effects in man are self-administered by laboratory animals.

Volume 238, Issue 3, pp. 924-931, 09/01/1986
Copyright © 1986 by American Society for Pharmacology and Experimental Therapeutics




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Copyright © 1986 by the American Society for Pharmacology and Experimental Therapeutics.