![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
GR Breese, TC Napier and RA Mueller
Locomotor responses caused by dopamine receptor agonists with presumed specificity for D-1 or D-2 receptor subtypes were compared to apomorphine-induced locomotion in neonatally and adult 6- hydroxydopamine (6-OHDA)-treated rats. In adult 6-OHDA-treated rats, apomorphine and the D-2 agonist, LY-171555, produced a marked, dose- related increase in locomotor activity. Increases in locomotion observed in neonatally 6-OHDA-treated rats after apomorphine and LY- 171555 administration were less than one-third of those seen in rats treated as adults with 6-OHDA. Neonatally 6-OHDA-treated rats, positive for L-dihydroxyphenylalanine-induced self-biting, exhibited a small increase in locomotion after a single exposure to SKF-38393, a D-1 dopamine agonist. Subsequent administration of SKF-38393 to these rats resulted in an additional elevation of the locomotor response which reached a maximum after four doses. Adult 6-OHDA-treated rats were less sensitive to the locomotor stimulant effects of SKF-38393 than were neonatally 6-OHDA-treated rats. SKF-38393 and LY-171555 produced several behaviors in neonatally 6-OHDA-treated rats that were similar. These results indicate that D-1 dopamine receptors contribute to modulation of central dopaminergic function. Haloperidol and cis- flupentixol antagonized apomorphine-induced locomotion comparably in control and adult 6-OHDA-treated rats. The D-1 dopamine receptor antagonist, SCH-23390, was a less effective blocker of apomorphine- induced locomotion in 6-OHDA-treated rats than in controls. Therefore, the ability of SCH-23390 to attenuate apomorphine in control rats is likely dependent upon intact catecholamine-containing neurons.(ABSTRACT TRUNCATED AT 250 WORDS)
This article has been cited by other articles:
|
|
 |
|
  S. T. Papadeas, B. L. Blake, D. J. Knapp, and G. R. Breese Sustained Extracellular Signal-Regulated Kinase 1/2 Phosphorylation in Neonate 6-Hydroxydopamine-Lesioned Rats after Repeated D1-Dopamine Receptor Agonist Administration: Implications for NMDA Receptor Involvement J. Neurosci., June 30, 2004; 24(26): 5863 - 5876. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. H. Chartoff, B. T. Marck, A. M. Matsumoto, D. M. Dorsa, and R. D. Palmiter Induction of stereotypy in dopamine-deficient mice requires striatal D1 receptor activation PNAS, August 17, 2001; (2001) 181356498. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Noda, Y. Miyamoto, T. Mamiya, H. Kamei, H. Furukawa, and T. Nabeshima Involvement of Dopaminergic System in Phencyclidine-Induced Place Preference in Mice Pretreated with Phencyclidine Repeatedly J. Pharmacol. Exp. Ther., July 1, 1998; 286(1): 44 - 51. [Abstract] [Full Text]
|
|
|
|
|
|
N. Laprade, F. Radja, T. A. Reader, and J.-J. Soghomonian Dopamine Receptor Agonists Regulate Levels of the Serotonin 5-HT2A Receptor and its mRNA in a Subpopulation of Rat Striatal Neurons J. Neurosci., June 1, 1996; 16(11): 3727 - 3736. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. H. Chartoff, B. T. Marck, A. M. Matsumoto, D. M. Dorsa, and R. D. Palmiter Induction of stereotypy in dopamine-deficient mice requires striatal D1 receptor activation PNAS, August 28, 2001; 98(18): 10451 - 10456. [Abstract] [Full Text] [PDF]
|
|
 |
 |
 |
|
 |
 |
 |
