JPET Introducing ALZET?ew Model 2006 Pump

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Dose-dependent sulfoconjugation of salicylamide in dogs: effect of sulfate depletion or administration

JA Waschek, RM Fielding, SM Pond, GM Rubin, DJ Effeney and TN Tozer

The effects of plasma inorganic sulfate concentrations on the dose- dependent kinetics of salicylamide (SAM) were examined in the dog. Decreasing plasma sulfate concentrations from 0.9 mM to less than 0.3 mM significantly decreased clearance of a small dose of SAM (5 mg/kg) to the sulfate conjugate. Infusing sodium sulfate to prevent the decrease in plasma inorganic sulfate concentration that follows a p.o. 20-mg/kg dose of SAM did not increase SAM elimination. However, sodium sulfate given p.o. decreased SAM bioavailability, which suggests a local effect of sulfate on intestinal first-pass metabolism of SAM. These data show some dependence of SAM metabolism on plasma inorganic sulfate concentrations, but only when they are markedly reduced.

Volume 234, Issue 2, pp. 431-434, 08/01/1985
Copyright © 1985 by American Society for Pharmacology and Experimental Therapeutics






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Copyright © 1985 by the American Society for Pharmacology and Experimental Therapeutics.