![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
PC Churchill and MC Churchill
Previous studies by others have demonstrated that exogenous adenosine inhibits renin secretion in vivo. In the present experiments, we studied the effects of three adenosine receptor agonists [N6- cyclohexyladenosine (CHA), 2-chloroadenosine (2-CIA) and 5'-N- ethylcarboxamideadenosine (NECA)] on renin secretion of rat renal cortical slices. The effects were biphasic; submicromolar concentrations inhibited secretion concentration-dependently and the order of potency was CHA greater than 2-CIA greater than NECA. Micromolar and higher concentrations stimulated secretion concentration- dependently and the order of potency was reversed: NECA greater than 2- CIA greater than CHA. These results are consistent with the hypothesis that activation of A1 and A2 adenosine receptors produces inhibition and stimulation of secretion, respectively. Theophylline antagonized both the inhibitory effect of low concentrations of CHA and the stimulatory effect of higher concentrations, providing additional evidence for mediation by activation of cell-surface adenosine receptors. Calcium chelation abolished the inhibitory effect of CHA, suggesting that increased intracellular calcium mediates the inhibitory effect; on the other hand, the inhibitory effect was unaffected by membrane depolarization and calcium channel blockade, suggesting that CHA-induced inhibition is not due to calcium influx through voltage- sensitive calcium channels. Ouabain, vanadate and K-depolarization, all of which are believed to increase intracellular calcium, antagonized CHA- and NECA-stimulated renin secretion, suggesting that the stimulatory effect of these agonists is mediated by decreased intracellular calcium.(ABSTRACT TRUNCATED AT 250 WORDS)
This article has been cited by other articles:
|
|
 |
|
  V. Vallon, B. Muhlbauer, and H. Osswald Adenosine and kidney function. Physiol Rev, July 1, 2006; 86(3): 901 - 940. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Kim, D. Mizel, Y. G. Huang, J. P. Briggs, and J. Schnermann Adenosine as a mediator of macula densa-dependent inhibition of renin secretion Am J Physiol Renal Physiol, May 1, 2006; 290(5): F1016 - F1023. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Yao, M. Suwa, B. Li, K. Kawamura, T. Morioka, and T. Oite ATP-Dependent Mechanism for Coordination of Intercellular Ca2+ Signaling and Renin Secretion in Rat Juxtaglomerular Cells Circ. Res., August 22, 2003; 93(4): 338 - 345. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Hohne, M. O. Krebs, W. Boemke, E. Arntz, and G. Kaczmarczyk Evidence that the renin decrease during hypoxia is adenosine mediated in conscious dogs J Appl Physiol, May 1, 2001; 90(5): 1842 - 1848. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Virdis, L. Ghiadoni, M. Marzilli, E. Orsini, S. Favilla, P. Duranti, S. Taddei, P. Marraccini, and A. Salvetti Adenosine causes the release of active renin and angiotensin II in the coronary circulation of patients with essential hypertension J. Am. Coll. Cardiol., May 1, 1999; 33(6): 1677 - 1684. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Albinus, E. Finkbeiner, B. Sosath, and H. Osswald Isolated superfused juxtaglomerular cells from rat kidney: a model for study of renin secretion Am J Physiol Renal Physiol, December 1, 1998; 275(6): F991 - F997. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Ralevic and G. Burnstock Receptors for Purines and Pyrimidines Pharmacol. Rev., September 1, 1998; 50(3): 413 - 492. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. K. Dubey, Z. Mi, D. G. Gillespie, and E. K. Jackson Cyclic AMP–Adenosine Pathway Inhibits Vascular Smooth Muscle Cell Growth Hypertension, November 1, 1996; 28(5): 765 - 771. [Abstract] [Full Text]
|
|
|
|
|
|
R. K. Dubey, D. G. Gillespie, K. Osaka, F. Suzuki, and E. K. Jackson Adenosine Inhibits Growth of Rat Aortic Smooth Muscle Cells : Possible Role of A2b Receptor Hypertension, March 1, 1996; 27(3): 786 - 793. [Abstract] [Full Text]
|
|
|
|
|
|
X.-R. He, S. G. Greenberg, J. P. Briggs, and J. Schnermann Effects of Furosemide and Verapamil on the NaCl Dependency of Macula Densa–Mediated Renin Secretion Hypertension, July 1, 1995; 26(1): 137 - 142. [Abstract] [Full Text]
|
|
 |
 |
 |
|
 |
 |
 |
