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1 From the Laboratory of Pharmacology of the University of Oregon Medical School
The development of a decreased susceptibility to the diuretic action of caffein has been shown to occur in rabbits, requiring approximately four months for maximal development with large daily doses. The caffein tolerant rabbits remain in the best of health, apparently, with this large dosage of caffein over periods of twelve or more months.
The renal response of the rabbits exhibiting a maximal tolerance toward caffein was as sensitive toward minimal effective diuretic doses of sodium acetate as those responses obtained from the kidneys of control rabbits.
The urine of rabbits tolerant toward caffein showed no pathological constituent during the development of toleration or during its maintenance at maximal level.
Macroscopic and microscopic examination of the kidneys of caffein tolerant rabbits showed no particular pathology ascribable to the action of caffein.
Submitted on May 15, 1924
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