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Journal of Pharmacology And Experimental Therapeutics, Vol. 23, Issue 5, 385-393, 1924
Copyright © 1924 by American Society for Pharmacology and Experimental Therapeutics

A NEW METHOD OF TESTING LIVER FUNCTION WITH PHENOLTETRACHLORPHTHALEIN IV. THE RELATION OF IMPAIRED FUNCTION TO THE AMOUNT OF NORMAL LIVER TISSUE

SANFORD M. ROSENTHAL 1

1 From the Pharmacological Laboratory, The Johns Hopkins University

Variations in the phenoltetrachlorphthalein test can first be detected following the removal of approximately 12 per cent of the total liver substance in rabbits; when amounts greater than this are removed the degree of functional impairment bears a close and constant relation to the quantity of liver tissue removed. The curves of disappearance of the dye from the blood stream of rabbits have been standardized so that abnormal results in these animals can be interpreted in terms of actual percentage of impaired function.

Submitted on May 2, 1924






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Copyright © 1924 by the American Society for Pharmacology and Experimental Therapeutics.