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Journal of Pharmacology And Experimental Therapeutics, Vol. 23, Issue 5, 373-383, 1924
Copyright © 1924 by American Society for Pharmacology and Experimental Therapeutics

THE RESPONSE OF THE ISOLATED FROG HEART TO CHANGES IN HYDROGEN-ION CONCENTRATION AND ADRENALIN

WILLIAM SALANT 1 and R. L. JOHNSTON 1

1 From the Department of Physiology and Pharmacology, Medical Department of the University of Georgia, Augusta, Georgia

1. Acid Ringer's solutions caused depression in the frog heart which increased with greater hydrogen-ion concentrations.

2. Alkaline Ringer's solutions produced moderate stimulation.

3. Small amounts of adrenalin in Ringer's solutions of a pH 7.2 to 7.9 caused marked stimulation.

4. Adrenalin in acid solution also produced stimulation, but this was not pronounced, was transitory and occurred only when the force and frequency were marked before perfusion with the drug. The stimulation was sometimes followed by depression.

5. Adrenalin in acid solution likewise caused depression, and sometimes also cardiac irregularity when heart action was moderate or weak, the depression being greater when the concentration of hydrogen ions was increased.

6. The depressive action of adrenalin in acid solution was attributed to stimulation of inhibitory fibers in the cardiac sympathetic.

Submitted on April 28, 1924






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