![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
MK McMillian, SM Schanberg and CM Kuhn
Hepatic alpha-1, alpha-2 and beta-2 adrenoceptors were characterized during development of the rat through Scatchard analysis of [3H]prazosin, [3H]rauwolscine and [125I]pindolol binding to liver membrane preparations. Major changes in adrenoceptor numbers occur shortly before birth at weaning. The fetal rat liver is characterized by a large number of alpha-2 adrenoceptors, which falls 10-fold by birth. The number of hepatic beta-2 adrenoceptors decreases gradually during development, and is lower at all times than the number of alpha- 1 and alpha-2 adrenoceptors. The developmental profile of the hepatic alpha-1 adrenoceptor is biphasic: there is a 2 to 3-fold fall in alpha- 1 adrenoceptor number at birth and a 3- to 5-fold rise at weaning. While absolute numbers of alpha-1 and beta-2 adrenoceptors do not correlate precisely with reported actions of epinephrine and norepinephrine on hepatic metabolism during ontogeny, the increasing ratio of alpha-1/beta-2 hepatic adrenoceptors may contribute to the conversion from predominantly beta effects of catecholamines reported in fetal and suckling rat liver to the predominantly alpha-1 effects that are well documented in the adult male rat.
This article has been cited by other articles:
|
|
 |
|
  L. Erraji-Benchekroun, D. Couton, C. Postic, I. Borde, J. Gaston, J.-G. Guillet, and C. Andre Overexpression of {beta}2-adrenergic receptors in mouse liver alters the expression of gluconeogenic and glycolytic enzymes Am J Physiol Endocrinol Metab, April 1, 2005; 288(4): E715 - E722. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. T. Auman, F. J. Seidler, C. A. Tate, and T. A. Slotkin beta -Adrenoceptor-mediated cell signaling in the neonatal heart and liver: responses to terbutaline Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2001; 281(6): R1895 - R1901. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. T. Auman, F. J. Seidler, and T. A. Slotkin Regulation of fetal cardiac and hepatic beta -adrenoceptors and adenylyl cyclase signaling: terbutaline effects Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2001; 281(4): R1079 - R1089. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Garofolo, F. J. Seidler, J. T. Auman, and T. A. Slotkin beta -Adrenergic modulation of muscarinic cholinergic receptor expression and function in developing heart Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2002; 282(5): R1356 - R1363. [Abstract] [Full Text] [PDF]
|
|
 |
 |
 |
|
 |
 |
 |
