Behavioral effects of buprenorphine and diprenorphine under a multiple schedule of food presentation in squirrel monkeys

LA Dykstra

The effects of buprenorphine and diprenorphine were examined in squirrel monkeys responding under a multiple fixed-ratio, fixed- interval schedule of food presentation. Buprenorphine (0.003-1.0 mg/kg) produced dose-dependent decreases in rates of responding under both components of the multiple schedule. These effects of buprenorphine (greater than 0.03 mg/kg) were still apparent 1 and 2 days after administration. Diprenorphine decreased rates of responding in a manner similar to that of buprenorphine; however, diprenorphine was less potent than buprenorphine and its duration of action was shorter. Buprenorphine-induced decreases in rates of responding under both components of the multiple schedule were antagonized by naloxone (0.1- 1.0 mg/kg), whereas those of diprenorphine were not. At 0.3 mg/kg of naloxone the buprenorphine dose-effect curve was shifted approximately 1 log U to the right. Buprenorphine did not antagonize morphine-induced decreases in rates of responding under the multiple schedule; however, effects of morphine were antagonized by both naloxone and diprenorphine. Finally, the effects of buprenorphine were not attenuated when buprenorphine was administered once daily for 17 days.

Volume 226, Issue 2, pp. 317-323, 08/01/1983
Copyright © 1983 by American Society for Pharmacology and Experimental Therapeutics

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