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Effect of ethanol-containing liquid diet upon gonadotropin receptor depletion in rat testis

PA Gantt, PT Tho, VK Bhalla, PG McDonough, A Costoff and VB Mahesh

By using pair-feeding technique, the number of gonadotropin binding sites per unit mass of testicular homogenate was measured 15, 30, 45 and 60 days after ethanol administration to 60-day-old male rats. The ingestion of ethanol (5%, v/v) as a part of a nutritionally adequate liquid diet resulted in 30, 35 and 40% reduction in gonadotropin receptors by 15, 30 and 45 days, respectively. The body weights in the alcohol-fed rats were comparable to pair-fed controls. These findings suggest that the presence of ethanol in the liquid diet depresses the level of gonadotropin receptors in the rat testis.

Volume 223, Issue 3, pp. 848-853, 12/01/1982
Copyright © 1982 by American Society for Pharmacology and Experimental Therapeutics






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Copyright © 1982 by the American Society for Pharmacology and Experimental Therapeutics.