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Involvement of endogenous prostaglandin I2 in the vascular action of histamine in dogs

N Toda, M Konishi and M Miyazaki

In helical strips of dog mesenteric and gastroepiploic arteries contracted with prostaglandin (PG) F2 alpha, the addition of histamine (10(-6) M) caused a relaxation, which was markedly attenuated by treatment with aspirin, indomethacin or tranylcypromine. Treatment with chlorpheniramine prevented the inhibitory effect of aspirin or tranylcypromine. Combined treatment with chlorpheniramine plus aspirin or tranylcypromine slowed the development of histamine-induced relaxations as did the treatment with chlorpheniramine alone. Relaxations of mesenteric and gastroepiploic arteries induced by histamine were markedly attenuated or abolished by combined treatment with chlorpheniramine and cimetidine. Histamine-induced relaxations of coronary and renal arterial strips were suppressed by cimetidine alone but were unaffected by aspirin. Contractile responses of cerebral arterial strips to histamine were attenuated by chlorpheniramine and potentiated by aspirin. The collagen-induced platelet aggregation was inhibited by treatment with bathing media in which mesenteric arteries were stimulated by histamine; the inhibition was prevented by treatment of the arteries with aspirin. It may be concluded that relaxation of mesenteric and gastroepiploic arteries induced by histamine is mainly associated with the release of prostaglandin I2 from the arterial wall, which results from an activation of histaminergic H1 receptors. Histamine-induced cerebroarterial contractions mediated via H1 receptors appear to be partly counteracted by prostaglandin I2 released.

Volume 223, Issue 1, pp. 257-262, 10/01/1982
Copyright © 1982 by American Society for Pharmacology and Experimental Therapeutics




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Copyright © 1982 by the American Society for Pharmacology and Experimental Therapeutics.