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Interaction between the renin-angiotensin and beta adrenergic nervous systems in drinking and pressor responses after renal artery constriction

J Atkinson, P Luthi, R Pera-Bally and L Peters-Haefeli

Constriction of the remaining renal artery of a uninephrectomized rat produced an increase in plasma renin level, a decrease in renal cortex renin level, an increase in blood pressure and a drinking response. Simultaneous infusion with the angiotensin II antagonist, saralasin, potentiated the rise in plasma renin level and blocked the rise in blood pressure. Drinking was only partially attenuated. Pretreatment with l-propranolol had no effect on the changes in plasma or kidney renin levels, but the increase in blood pressure was potentiated and the drinking response was attenuated. It is concluded that the pressor and drinking responses to renal artery constriction are partially mediated by the beta adrenergic nervous system.

Volume 221, Issue 2, pp. 453-460, 05/01/1982
Copyright © 1982 by American Society for Pharmacology and Experimental Therapeutics






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Copyright © 1982 by the American Society for Pharmacology and Experimental Therapeutics.