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Journal of Pharmacology And Experimental Therapeutics, Vol. 22, Issue 1, 21-34, 1923
Copyright © 1923 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF LIGHT ON THE BEHAVIOR OF RATS AFTER INJECTIONS OF QUININ AND QUINIDIN SULPHATES

DAVID I. MACHT 1 and ELMER J. TEAGRADEN JR. 1

1 From the Pharmacological Labaratory, the Johns Hopkins University

The effect of light on the behavior of normal rats and of rats injected with solutions of quinin and quinidin sulphates was studied in respect to their behavior in the circular maze. It was found that:

1. Sunlight and ultraviolet radiations from a quartz lamp produce either no effect or a stimulating effect on normal rats.

2. The pharmacological activity of quinin and quinidin sulphates was greater in animals exposed to light than those kept in darkness.

3. The absolute lethal doses of quinin and quinidin were smaller for animals kept in light than for those kept in darkness.

4. As between the two optic isomers quinin and quinidin, the leavo-gyrous variety (quinin) was more toxic than the dextro-gyrous variety (quinidin).

Submitted on July 12, 1923






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