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Cardiovascular effects of lysophosphatidic acid and its structural analogs in rats

A Tokumura, T Kume, K Fukuzawa and H Tsukatani

Injection of lysophosphatidic acid into anesthetized rats induced immediate hypertension, the effect depending on the structure of the sn- 1-acyl moiety of the molecule. A hydroxyl group at the sn-2-position was not necessary, but a wedgeshaped structure was suitable for hypertensive activity. Most lysophospholipids with a chemical group attached to the phosphate portion had only weak hypotensive effects, but the sn-2-acetylated analogs of these depressor lysophospholipids elicited a hypotension at much lower doses. The durations of the hypotensions evoked by the sn-2-acetylated choline phospholipids were longer than those produced by 1-palmitoyl-2-acetoyl-sn-glycerol-3- phosphorylmethanol, ethanol and propanol.

Volume 219, Issue 1, pp. 219-224, 10/01/1981
Copyright © 1981 by American Society for Pharmacology and Experimental Therapeutics




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Copyright © 1981 by the American Society for Pharmacology and Experimental Therapeutics.