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The effect of chronic lithium treatment on rat pineal N- acetyltransferase rhythm

E Friedman and FD Yocca

Lithium chloride administration to rats for 5 weeks caused a significant decrease in dark-induced activity of rat pineal N- acetyltransferase (E.C.2.3.1.5.). This effect is not observed after 3 days or 3 weeks of treatment. Furthermore, chronic lithium treatment suppressed the amplitude and may have delayed the peak of the diurnal cycle of N-acetyltransferase activity. In vitro, various concentrations of lithium chloride (2, 4 and 10 microM) did not affect N- acetyltransferase activity. Beta adrenergic receptor binding studies with [3H]dihydroalprenolol indicated a decrease in number of pineal beta adrenergic receptors in rats treated chronically with lithium. These results are consistent with a lithium-induced subsensitivity of pineal beta adrenergic receptors and may explain the effect of lithium on pineal-mediated cyclic behaviors.

Volume 219, Issue 1, pp. 121-124, 10/01/1981
Copyright © 1981 by American Society for Pharmacology and Experimental Therapeutics






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Copyright © 1981 by the American Society for Pharmacology and Experimental Therapeutics.