JPET Introducing ALZET?ew Model 2006 Pump

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Jason, K. M.
Right arrow Articles by Friedman, E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jason, K. M.
Right arrow Articles by Friedman, E.

Prenatal exposure to imipramine alters early behavioral development and beta adrenergic receptors in rats

KM Jason, TB Cooper and E Friedman

Offspring of rats exposed to water or 15 mg/kg/dy of imipramine (IMI) on gestational day 8 through 20 were examined for behavioral and neurochemical development. IMI-treated mothers gained significantly less weight during pregnancy, but the percentage giving birth, length of gestation and litter size were unaffected. Body weights of IMI- exposed offspring were significantly lower than controls until postnatal day 14 and brain weights were lower until day 30. In IMI- exposed pups, eye-opening occurred significantly earlier, development of the surface righting reflex was delayed and development of negative geotaxis was altered. Hypothalamic levels of noradrenaline and adrenaline were unchanged in IMI pups at 7, 14 and 30 days, but dopamine levels, unaffected at 7 and 14 days, were significantly lower than controls at 30 days. The number of cortical beta adrenergic receptors, measured by [3H]dihydroalprenolol binding, was significantly decreased by 18.7% at 14 days and 9.1% at 30 days. Affinity for binding was increased at 30 days. Brain levels of IMI and its metabolite desmethylimipramine were detectable in newborns prenatally exposed to IMI and desmethylimipramine/IMI ratios were 1.8 times those found in adults. The results indicate that prenatal exposure to IMI produces behavioral and neurochemical consequences lasting well past cessation of drug exposure.

Volume 217, Issue 2, pp. 461-466, 05/01/1981
Copyright © 1981 by American Society for Pharmacology and Experimental Therapeutics




This article has been cited by other articles:


Home page
 J. Neurosci.Home page
M. S. Ansorge, E. Morelli, and J. A. Gingrich
Inhibition of Serotonin But Not Norepinephrine Transport during Development Produces Delayed, Persistent Perturbations of Emotional Behaviors in Mice
J. Neurosci., January 2, 2008; 28(1): 199 - 207.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
L. G. Costa, L. Steardo, and V. Cuomo
Structural Effects and Neurofunctional Sequelae of Developmental Exposure to Psychotherapeutic Drugs: Experimental and Clinical Aspects
Pharmacol. Rev., March 1, 2004; 56(1): 103 - 147.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
P. S. Zeskind and L. E. Stephens
Maternal Selective Serotonin Reuptake Inhibitor Use During Pregnancy and Newborn Neurobehavior
Pediatrics, February 1, 2004; 113(2): 368 - 375.
[Abstract] [Full Text] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1981 by the American Society for Pharmacology and Experimental Therapeutics.