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Interaction of ethanol and inorganic mercury: generation of mercury vapor in vivo

JD Dunn, TW Clarkson and L Magos

Mercury exhalation increased after parenteral administration of ethanol to mice injected with a single dose of mercuric chloride (0.5 mg of Hg/Kg). Increased output of the metal was ethanol dose-dependent (blood EC50 = 215 mg/dl) and maximal rates (0.2% of the body burden per 30 min) were about 10-fold higher than controls. The chemical form of exhaled mercury was determined to be the elemental vapor (Hg degrees) indicating an ethanol-sensitive reduction pathway for ionic mercury (Hg++) in the body. Ethanol appeared to selectively affect mercury exhalation inasmuch as no large differences in whole-body mercury retention times or in the distribution of the metal in organs could be detected even after repeated daily doses of ethanol. The results show that at least a portion of the ionic mercury in the body can be mobilized via reduction and Hg++ in tissues is more labile than generally recognized.

Volume 216, Issue 1, pp. 19-23, 01/01/1981
Copyright © 1981 by American Society for Pharmacology and Experimental Therapeutics




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M D Martin and C Naleway
The inhibition of mercury absorption by dietary ethanol in humans: cross-sectional and case-control studies
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J. Dunn, T. Clarkson, and L Magos
Ethanol reveals novel mercury detoxification step in tissues
Science, September 4, 1981; 213(4512): 1123 - 1125.
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Copyright © 1981 by the American Society for Pharmacology and Experimental Therapeutics.