Clonidine-induced hyperglycemia: evidence against a growth hormone- mediated effect

C Barbieri, C Ferrari, R Caldara, G Testori, GA Dal Bo and A Bertazzoni

The effects of acute clonidine infusion (0.15 mg over 10 min) on several endocrine and metabolic variables have been evaluated in 12 hypertensive patients and 12 normotensive controls. Plasma glucose increased significantly in comparison with a placebo study in both groups; serum growth hormone showed a significant increase in healthy subjects but did not rise in hypertensive patients; there was no correlation between the increments in plasma glucose and in serum growth hormone in the whole group of subjects; serum-free fatty acids, insulin, prolactin and plasma cortisol did not change in any group. These data, although not excluding a central site of the clonidine hyperglycemic action, contrast the view that it may depend on stimulation of growth hormone release.

Volume 214, Issue 2, pp. 433-436, 08/01/1980
Copyright © 1980 by American Society for Pharmacology and Experimental Therapeutics

This article has been cited by other articles:

				R. A. Velliquette and P. Ernsberger The Role of I1-Imidazoline and {alpha}2-Adrenergic Receptors in the Modulation of Glucose Metabolism in the Spontaneously Hypertensive Obese Rat Model of Metabolic Syndrome X J. Pharmacol. Exp. Ther., August 1, 2003; 306(2): 646 - 657. [Abstract] [Full Text] [PDF]