JPET

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sakurai, T.
Right arrow Articles by Abelmann, W. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sakurai, T.
Right arrow Articles by Abelmann, W. H.

Effects of acetaldehyde upon mechanical properties of isolated rat papillary muscle

T Sakurai, OH Bing, G Huber and WH Abelmann

The acute effects of acetaldehyde upon the performance of isolated rat papillary muscle were studied. At high concentrations (50 and 100 mg/100 ml), acetaldehyde demonstrated a negative inotropic effect and abbreviated relaxation time. Pretreatment with either propranolol or reserpine unmasked a direct negative inotropic effect of acetaldehyde at concentrations as low as 5 mg/100 ml. The shortening of relaxation was also blocked by propranolol and reserpine. These findings are compatible with both a direct myocardial depressant effect and an indirect beta-stimulatory effect of acetaldehyde. In the range of concentrations encountered clinically, however, acetaldehyde is not likely to have a significant acute effect upon cardiac muscle performance.

Volume 214, Issue 1, pp. 219-222, 07/01/1980
Copyright © 1980 by American Society for Pharmacology and Experimental Therapeutics






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1980 by the American Society for Pharmacology and Experimental Therapeutics.