Inability of indomethacin to modify hydrochlorothiazide diuresis and natriuresis by the chimpanzee kidney

GM Fanelli , DL Bohn, AE Camp and WK Shum

A drug interaction study in the chimpanzee by using indomethacin and hydrochlorothiazide has shown conclusively that the diuretic and saluretic properties of hydrochlorothiazide were not compromised by indomethacin. This was true whether hydrochlorothiazide or indomethacin was administered first. The renal clearance of hydrochlorothiazide was not influenced by indomethacin nor was the renal clearance of indomethacin significantly altered by hydrochlorothiazide. Indomethacin alone caused a small but significant increase in sodium, potassium and chloride excretion and in Curate/glomerular filtration rate. In control experiments with placebo, potassium excretion was also significantly increased. The implications of these observations remain obscure. In all experiments utilizing hydrochlorothiazide, the well known renal effects of this agent were clearly evident under these experimental conditions.

Volume 213, Issue 3, pp. 596-599, 06/01/1980
Copyright © 1980 by American Society for Pharmacology and Experimental Therapeutics