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Mechanism of the antihypertensive action of clonidine on the pressor response to physostigmine

JJ Buccafusco, JP Finberg and S Spector

Physostigmine (P) was used as a model in anesthetized rats for the development of hypertension by a central cholinergic mechanism. P (25- 100 micrograms/kg i.v.) produced a dose-related increase in mean arterial pressure which was inhibited 30 to 90% by preinjection of clonidine (100 micrograms/kg i.v.). This dose of clonidine was without effect on the pressor response to ganglionic stimulation produced by 1,1-dimethyl-4-phenylpipera-zinium iodine. To examine further the central inhibitory effect of clonidine on the pressor response to P, regional brain acetylcholine turnover rate was measured in control and clonidine-pretreated rats. Clonidine significantly reduced turnover in hypothalamus (69%), pons-medulla (43%) and midbrain (39%) but not in striatum or hippocampus. These observations are consistent with an inhibitory effect of clonidine on central cholinergic neurons involved in cardiovascular regulation.

Volume 212, Issue 1, pp. 58-63, 01/01/1980
Copyright © 1980 by American Society for Pharmacology and Experimental Therapeutics




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H. E. De Wardener
The Hypothalamus and Hypertension
Physiol Rev, October 1, 2001; 81(4): 1599 - 1658.
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